2019, Number 3
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Rev Med Inst Mex Seguro Soc 2019; 57 (3)
First report of infectious endocarditis due to Histoplasma capsulatum in Mexico
Méndez-Tovar LJ, Rangel-Delgado PM, Hernández-Hernández F, Flores-García A, Galicia-Castelán G, Manzano-Gayosso P, Córdova ME
Language: Spanish
References: 29
Page: 181-186
PDF size: 395.37 Kb.
ABSTRACT
Background: Infectious endocarditis of fungal origin is rare but of high mortality. The agents involved are mainly opportunists of the genus
Candida and
Aspergillus; however other fungi can also cause this disease.
Clinical case: The case of a woman who suffered unknown origin intermittent fever for several months; and in who, by blood culture (after lysis-centrifugation) and molecular biology techniques,
Histoplasma capsulatum was identified as etiological agent. The histological study showed abundant intracellular yeasts and hyphae in intracardiac vegetations.
Conclusion: This first report of infectious endocarditis by
H. capsulatum in Mexico highlights the importance of using in addition to manual blood culture (lysis-centrifugation) and histological study, faster and more sensitive diagnostic methods, such as serology and molecular biology, to confirm or rule out an invasive fungal infection and identify the agents.
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