2019, Number 3
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Revista Cubana de Obstetricia y Ginecología 2019; 45 (3)
Association between blastocystosis and iron deficiency anemia in pregnant women in La Lisa Municipality, Havana, Cuba
Aleaga SY, Domenech CI, De Armas RY, Núñez FF, Fonte GL
Language: Spanish
References: 29
Page: 1-10
PDF size: 305.96 Kb.
ABSTRACT
Introduction: Recent studies found an association between blastocystosis and iron deficiency anemia. One of them showed that the infection with Blastocystis spp is a risk factor for in pregnant women to suffer. This infection can have adverse consequences for both the mother and the fetus. In extreme cases it can lead to maternal and fetal mortality.
Objective: To know the prevalence of blastocystosis in pregnant women and its possible association with iron deficiency anemia.
Methods: A parasitological, clinical and epidemiological study, descriptive and cross-sectional was conducted on the universe of pregnant women treated in three clinics in La Lisa municipality from July 2017 to June 2018.
Results: We found 43 (31.9%) pregnant women infected by parasitic protozoa out of 135 who were studied. Blastocystis spp, was the most prevalent (28.9%). 41 pregnant women suffered from anemia. In most of them (85.4%), anemia classified as iron deficiency. The proportion of pregnant women parasitized by Blastocystis spp who suffered from this type of anemia was significantly higher (p <0.05) in relation to pregnant women who were not infected by that protozoan and also suffered from that type of anemia.
Conclusions: Blastocystosis is a parasitosis of increasing prevalence which is insufficiently known. Initiatives to improve knowledge, perceptions and practices are peremptory to their diagnosis, treatment and control at the general and academic levels. The communication strategies that are implemented should inform about possible clinical consequences of this infection in pregnant woman.
REFERENCES
Scanlan PD. Blastocystis: past pitfalls and future perspectives. Trends Parasitol. 2012;28:327-34.
Boorom K. Behavior al decision analysis and pathogenicity: How do we decide what makes us sick? H. Mehlhorn et al. (eds.), Blastocystis: Pathogen or passenger? Parasitol Res Monographs 4, Springer-Verlag Berlin Heidelberg. 2012:133-66.
Srichaipon N, Nuchprayoon S, Charuchaibovorn S, Sukkapan P, Sanprasert V. A simple genotyping method for rapid differentiation of Blastocystis subtypes and subtype distribution of Blastocystis spp. in Thailand. Pathogens 2019;8: DOI: 10.3390/pathogens8010038
Tan KS. New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev. 2008;21:639-65.
Meloni D, Sanciu G, Poirier P, El Alaoui H, Chabé M, Viscoglios E. Molecular subtyping of Blastocystis sp. Isolates from symptomatic patients in Italy. Parasitol Res. 2011;109:613-9.
Eroglu F, Genc A, Elgun G, Koltas IS. Identification of Blastocystis hominis isolates from asymptomatic and symptomatic patients by PCR. Parasitol Res. 2009;105:1589-92.
Rajamanikam A, Hooi HS, Kudva M, Samudi C, Kumar S. Resistance towards metronidazole in Blastocystis sp.: A pathogenic consequence. PLoS ONE 2019;14: e0212542. https:// doi.org/10.1371/journal.pone.0212542
Fonte L, González Z, Fong A, Méndez Y, Moreira Y. Patogenicidad de Blastocystis sp. Evidencias y mecanismos. Rev Cubana Med Trop. 2014;66.
Lepczyńska M, Dzika E. The influence of probiotic bacteria and human gut microorganisms causing opportunistic infections on Blastocystis ST3. Gut Pathog. 2019; 11:6. Disponible en: https://doi.org/10.1186/s13099-019-0287-8.
Tito RY, Chaffron S, Caenepeel C, Lima Méndez G, Wang J, Vieira-Silva S. Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota. Gut. 2018;0:1–10.
Srichaipon N, Nuchprayoon S, Charuchaibovorn S, Sukkapan P, Sanprasert V. A simple genotyping method for rapid differentiation of Blastocystis subtypes and subtype distribution of Blastocystis spp. in Thailand. Pathogens. 2019;8: DOI: 10.3390/pathogens8010038
Thergarajan G, Kumar S, Bhassu S, Omar SFBS, Rampal S. Effect of Blastocystis sp. In dengue patients—Increase in the treatment cost and exacerbation of symptoms. PLoS ONE 2019: 14: e0211034. Disponible en: https://doi.org/10.1371/journal.pone.0211034.
Yason JA, Liang Y, Wen C, Zhang Y, Tan K. Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies. Microbiome. 2019. Disponible en: https://doi.org/10.1186/s40168-019-0644-3
Cheng HS, Guo YL, Shin JW. Hematological effects of Blastocystis hominis infection in male foreign workers in Taiwan. Parasitol Res. 2003;90:48-51.
Yavasoglu I, Kadikoylu G, Uysal H, Ertug S, Bolaman Z. Is Blastocystis hominis a new etiologic factor or a coincidence in iron deficiency anemia? Eur J Haematol. 2008;81:47-50.
El Deeb HK, Khodeer S. Blastocystis spp.: frequency and subtype distribution in iron deficiency anemic versus non-anemic subjects from Egypt. J Parasitol. 2013;99:599-602.
Javaherizadeh H, Khademvatan S, Soltani S, Torabizadeh M, Yousefi E. Distribution of haematological indices among subjects with Blastocystis hominis infection compared to controls. Prz Gastroenterol. 2014;9:38-42.
El Deeb HK, Salah-Eldin H, Khodeer S. Blastocystis hominis as a contributing risk factor for development of iron deficiency anemia in pregnant women. Parasitol Res. 2012;110:2167-74.
Zavaleta N, Caulfield LE, Garci T. Changes in iron status during pregnancy in Peruvian women receiving prenatal iron and folic acid supplements with or without zinc. Am J Clin Nutr. 2000;71:956-61.
Ansari T, Ali L, Aziz A, Ara J, Liaquat N, Tahir H. Nutritional iron deficiency in women of child bearing age-what to do? J Ayub Med Coll Abbottabad. 2009;21:17-20.
Núñez FA, Cordoví RA. Manual de técnicas básicas para el diagnóstico de las parasitosis intestinales. Ciudad de La Habana: IPK/MINSAP/UNICEF; 2006.
Bick RL. Hematology: clinical and laboratory practice. St. Louis: Mosby; 1993.
Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood. 1993;81:1067-76.
Wintrobe MM. Clinical haematology. 10th ed. Philadelphia: Lea and Febiger; 1998.
Gay Rodríguez J, Padrón Herrera M, Amador M. Prevención y Control de la anemia y la deficiencia de hierro en Cuba. Rev Cubana Aliment Nutr. 1995;9:31-4.
Selva L, Abad A. Acciones para la prevención y control de la anemia por deficiencia de hierro en niños hasta cinco años. Rev Cubana Salud Pública. 2011;37:200-6.
Anlaakuu P, Anto F. Anaemia in pregnancy and associated factors: a cross sectional study of antenatal attendants at the Sunyani Municipal Hospital, Ghana. BMC Res Notes 2017; 10:402. DOI: 10.1186/s13104-017-2742-2.
Daru J, Zamora J, Borja M, Vogel J, Oladapo O, Khan K. Risk of maternal mortality in women with severe anaemia during pregnancy and post-partum: a multilevel analysis. Lancet Glob Health. 2018;6:e548-54.
Dirección Nacional de Registros Médicos y Estadísticas de Salud. Anuario estadístico nacional 2018. La Habana: MINSAP; 2019.