2019, Number 2
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Revista Cubana de Obstetricia y Ginecología 2019; 45 (2)
Risk factors for breast cancer
Milena BA, López AA, Cardona-Arias JA
Language: Spanish
References: 61
Page: 1-19
PDF size: 278.93 Kb.
ABSTRACT
Introduction: Breast cancer is most common among women; its risk factors have not been
outlined from a broad approach of published reviews.
Objective: To outline the risk factors of breast cancer from publications of case-control
studies from 2008 to 2018.
Methods: A systematic review of the literature based on the application of comprehensive
and reproducible protocol, following identification, screening, selection and inclusion
phases of PRISMA guide. Qualitative synthesis was performed with proportions and 95 %
confidence intervals.
Results: 298 studies were analyzed in 2,927,342 women, mostly from Mexico (2 000 835). The
countries with highest frequency of publication were USA. (20.9 %) and China (10.8 %). The
most studied groups of risk factors were diet (26.6 %), reproductive factors (14.8 %) and
lifestyle (9.1 %). The least studied are the biological ones. Only one approached this type of
factor, reporting a strong association of IgG seroconversion in cytomegalovirus with the
appearance of breast cancer. The three factors that registered the greatest strength of association
were obesity, psychosocial factors and cytomegalovirus.
Conclusions: We found a wide diversity of risk factors, some rigorous-design studies to
establish solid etiological associations and others with initial research development or
methodological problems that prevent consolidating causal hypotheses and therefore the
possibility of intervening in the main triggers for the appearance of the disease.
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