Alcaraz LJL

Language: Spanish
References: 10
Page: 39-42
PDF size: 74.68 Kb.

ABSTRACT

There are two types of delayed hemolytic effects of transfusion: primary immunization and anamnestic response. The first is mild, occurs several weeks after transfusion and is the result of primary aloimmunization; antibodies are detectable no earlier than 7-10 days after transfusion and usually several weeks or months later. The degree of hemolysis depends on the amount of antibody produced and the amount of transfused cell remaining. The second type occurs in a previously immunized recipient who experiences an anamnestic, or secondary response to transfused red cell antigens. The blood bank may detect a delayed hemolytic reaction, through serologic findings in patients without symptoms; most of the cases are asymptomatic. Positive antibody detection tests and crossmatch incompatibilities might be noted. Elution and identification of the antibody is critical before having another transfusion. It is important to carry out antibody detection tests and compatibility tests with additional techniques by Low Ionic Strength Salt Solution or enzyme techniques.

REFERENCES

1. Norma Oficial Mexicana NOM-003-SSA2-1993 para la disposición de sangre humana y sus componentes con fines terapéuticos. p. 38-40.

2. Recomendaciones para la Terapia Transfusional de Sangre y sus Componentes. Consenso de Expertos en Medicina Transfusional. Asociación Mexicana de Medicina Transfusional, AC. Comité de Medicina Transfusional de la AMEH; 2003. p. 36-48.

3. Rodríguez-Moyado R, Quintanar-García E, Mejía-Arregui M. El Banco de Sangre y la Medicina Transfusional. Distrito Federal, México: Médica Panamericana; 2004. p. 143-146.

4. Radillo-González A. Medicina Transfusional, Distrito Federal, México: Editorial Prado; 1999. p. 389-391.

5. Bonifaz-Gracias. Aspectos Clínicos en Medicina Transfusional. Distrito Federal, México: Intersistemas; 2004. p. 75-76.

6. Alcaraz-López JL, Bonilla R. Frecuencia de Anticuerpos irregulares antieritrocitos en pacientes ambulatorios. II Congreso Nacional de la AMMTAC. Trabajos libres. 2004: 27.

7. Murphy MF. Practical Transfusion Medicine. London, UK: Blackwell Science; 2002. p. 147-156.

8. Mollison PL, Engelfriet CP, Contreras M. Blood Transfusion in Clinical Medicine. London United Kingdom: Tenth edition. Cambridge, Mass: Blackwell Scientific; 1997. p. 187-205.

9. Branch DR. Technical Manual, American Association of Blood Banks. Eleventh edition. Bethesda, Maryland; 2002. p. 471-487.

10. Robillard P, Ki-Nawei. Four year cumulative incidence of serious adverse transfusion events in the Wuebec hemovigilance system. Immunologic reactions to transfusion. Vox Sanguinis 2005; 89 (3): 12-14.