Cervantes C

Language: Spanish
References: 19
Page: 67-71
PDF size: 349.58 Kb.

ABSTRACT

Arsenic derivatives are widely distributed in natural environments and the high toxicity of these compounds, both inorganic and organic, has converted their prevalence in a serious public health problem to a global level. It has been demonstrated that microorganisms play a relevant role in the geocycle in which participate arsenic and its derivatives. Continuous exposure to arsenic compounds has influenced for microorganisms to develop varied arsenic tolerance mechanisms. For inorganic arsenic derivatives, the microbial resistance strategies are commonly based on transport systems that extrude the toxic compounds from the cell cytoplasm. These systems are encoded in the widely distributed ars operons. More recently, novel mechanisms related to the microbial tolerance towards organic arsenic compounds have been discovered. These systems include the enzymes ArsM, ArsH and ArsI and the ArsP transporter, all of them able to destoxify the organoarsenicals.This review briefly summarizes the information on the function and distribution of the systems of resistance to organoarsenicals in prokaryotes.

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