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2019, Number 2

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Rev Cubana Hematol Inmunol Hemoter 2019; 35 (2)

Evaluation of joint leakage of national Chromic Phosphate labeled with Phosphorus-32 in hemophilic patients

Fundora STA, Echevarría CF, Hernández RH

Language: Spanish
References: 13
Page: 1-11
PDF size: 385.07 Kb.


ABSTRACT

Radiosynoviorthesis as a treatment for hemophilic arthropathy often offers excellent results, greatly reducing the number of bleeding episodes and avoiding further damage to the joints. The Isotope Center developed a product, Colloidal Chromic Phosphate labeled with Phosphorus-32, ready for use in hemophiliac patients. Our objective was to evaluate the joint leakage of this radiopharmaceutical use in radiosynoviorthesis in hemophilic patients. The percentage of radiopharmaceutical joint leakage was evaluated in 9 hemophilic patients with chronic synovitis, who underwent radiosynoviorthesis in the knee joint. The radioactivity was measured on the treated knee, in its lateral, above and medial aspects, the contralateral knee, the inguinal lymphatic chains of both sides and the liver, with a Geiger-Muller detector. The leakage values found after the injection were 0.0046% at 10 minutes, 0.0023% at 24 hours, 0.1332% on day 7 and 4.0213% on day 30. These results are agreed with the values reported by other authors and with was expected according to the characteristics of the product, indicatate that the procedure was executed properly and that the patients were correctly selected.


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