medigraphic.com
ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2019, Number 2

<< Back Next >>

Rev Cubana Hematol Inmunol Hemoter 2019; 35 (2)

Immune thrombocytopenia primary and cytomegalovius, Epstein Barr virus infection: immunosuppression versus autoimmunity

Adams VY, Castillo GD

Language: Spanish
References: 34
Page: 1-13
PDF size: 360.91 Kb.


ABSTRACT

Primary immune thrombocytopenia is associated with multiple factors that may lead to loss of self-tolerance to the antigens on the surface of platelets and megakaryocytes. Several infectious agents have been implicated. Herpes viruses due to the high prevalence in the population and tropism by the lymphoid cells have been related to the development of this entity. A bibliographic review was made using search engines such as Ebsco and Pubmed that allowed access to related articles in magazines arbitrated. Information was collected and organized that involved the role of cytomegalovirus and EBV infection in the development of ITP. Most of the articles indicate that in these viruses, the non-cytolytic nature of replication favors the time of interaction and modulation on host cells that are frequently B, T and natural killer lymphocytes. Timely diagnosis and appropriate therapy in these patients contributes to the immunomodulation of self-reactivity and viral elimination, in the light of current knowledge, is essential for integrated clinical treatment. Consider monitoring the serological and molecular status of these herpes viruses in patients in whom the natural history of the disease suggests their association, especially in primary or secondary immune thrombocytopenia; by the high level of relation of the mechanisms of production of the autoimmunity, the dysmielopoyesis and the lymph proliferation with the pathogenesis of the infection by these viruses.


REFERENCES

  1. Komatsu N. Recent progress of diagnosis and treatment for immune-mediated hematological diseases. Topics: III. Diagnosis and treatment; 1. Immune thrombocytopenic purpura (immune thrombocytopenia). Nihon Naika Gakkai Zasshi. 2014 Jul 10;103(7):1593-8.

  2. Kashiwagi H, Tomiyama Y. Management of idiopathic thrombocytopenic purpura (primary immune thrombocytopenia, ITP). Rinsho Ketsueki. 2014 Oct;55(10):2087-94.

  3. Monteagudo E, Fernández-Delgado R, Sastre A, Toll T, Llort A, Molina J, et al. Protocol for the study and treatment of immune thrombocytopenic purpura (ITP). ITP-2010. An Pediatr (Barc). 2011 Jun;74(6):414 e1-8.

  4. Perricone C, Ceccarelli F, Nesher G, Borella E, Odeh Q, Conti F, et al. Immune thrombocytopenic purpura (ITP) associated with vaccinations: a review of reported cases. Immunol Res. 2014 Dec;60(2-3):226-35.

  5. Wang D, Hu SL, Cheng XL, Yang JY. FCGR2A rs1801274 polymorphism is associated with risk of childhood-onset idiopathic (immune) thrombocytopenic purpura: evidence from a meta-analysis. Thromb Res. 2014 Dec;134(6):1323-7.

  6. Raynard Ortiz M, Jamart V, Cambray C, Borras R, Mailan, J. Manejo anestésico en gestante afecta de púrpura trombocitopénicaidiopática. Rev Esp Anestesiol Reanim. 2009;56(3):185-8.

  7. Keith McCrae M. Immune thrombocytopenia: No longer ‘idiopathic. Cleve Clin J Med. 2011 june;78(6): 358-73. doi: 10.3949/ccjm.78gr.10005

  8. von Laer Tschudin L, Schwitzgebel VM, von Scheven-Gete A, Blouin JL, Hofer M, Hauschild M, et al. Diabetes and immune thrombocytopenic purpura: a new association with good response to anti-CD20 therapy. Pediatr Diabetes. 2014 Mar;16(2):138-45.

  9. Kistangari G, McCrae KR. Immune thrombocytopenia. Hematol Oncol Clin North Am. 2013 Jun;27(3):495-520.

  10. Saeidi S, Jaseb K, Asnafi AA, Rahim F, Pourmotahari F, Mardaniyan S, et al. Immune Thrombocytopenic Purpura in Children and Adults: A Comparative Retrospective Study in IRAN. Int J Hematol Oncol Stem Cell Res. 2015 Jul 1;8(3):30-6.

  11. Rohmer B, Valla FV, Baleydier F, Launay V, Dommange-Romero F, Pondarre C. Newly diagnosed immune thrombocytopenic purpura in childhood: successful implementation of a limited intervention strategy in the setting of pediatric emergency care. J Pediatr. 2014 Feb;166(2):480-2.

  12. Vinayek N, Sharma V. A combination of bortezomib and rituximab yields a dramatic response in a woman with highly refractory immune thrombocytopenic purpura: a case report. J Med Case Rep. 2014;8:19.

  13. Patel AP, Patil AS. Dapsone for immune thrombocytopenic purpura in children and adults. Platelets. 2014;26(2):164-7.

  14. Arandi N, Mirshafiey A, Jeddi-Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, et al. Alteration in frequency and function of CD4(+)CD25(+)FOXP3(+) regulatory T cells in patients with immune thrombocytopenic purpura. Iran J Allergy Asthma Immunol. 2014 Apr;13(2):85-92.

  15. El Sissy MH, El Sissy AH, Elanwary S. Tumor necrosis factor-alpha -308G/A gene polymorphism in Egyptian children with immune thrombocytopenic purpura. Blood Coagul Fibrinolysis. 2014 Jul;25(5):458-63.

  16. Bergmann AK, Grace RF, Neufeld EJ. Genetic studies in pediatric ITP: outlook, feasibility, and requirements. Ann Hematol. 2010 Jul;89 Suppl 1:S95-103.

  17. El Neanaey WA, Barakat SS, Ahmed MA, El Nabie WM, Ahmed ME. The relation between HLA-DRB1 alleles and the outcome of therapy in children with idiopathic thrombocytopenic purpura. Egypt J Immunol. 2005;12(2):29-38.

  18. Yao R, Lin Y, Li Q, Zhou X, Pan X, Bao Y, et al. Downregulation of T-bet/GATA-3 ratio induced by IL-11 treatment is responsible for Th1/Th2 balance restoration in human immune thrombocytopenic purpura (ITP). J Thromb Thrombolysis. 2014;38(2):183-9.

  19. Gernsheimer T. Chronic idiopathic thrombocytopenic purpura: mechanisms of pathogenesis. Oncologist. 2009 Jan;14(1):12-21.

  20. Hai-Ping Tang, Jian-Guo Tan. Relationship between Th17 and Th22 in patients with primary immune thrombocytopenia. J Hainan Med University. 2016; 22(2):44-7.

  21. Teawtrakul N, Sawadpanich K, Sirijerachai C, Chansung K, Wanitpongpun C. Clinical characteristics and treatment outcomes in patients with Helicobacter pylori-positive chronic immune thrombocytopenic purpura. Platelets. 2014;25(7):548-51.

  22. Noonavath RN, Lakshmi CP, Dutta TK, Kate V. Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura. World J Gastroenterol. 2014 Jun 14;20(22):6918-23.

  23. Kobayashi Y, Hatta Y, Uchino Y. Successful treatment of secondary Helicobacter pylori eradication for chronic immune thrombocytopenic purpura. Platelets. 2014 2014;25(8):645.

  24. Coelho R, Nunes AC, Macedo G. Endoscopic findings of immune thrombocytopenic purpura: "gastric footprints". Endoscopy. 2014;46 Suppl 1 UCTN:E554.

  25. Fields BN, Knipe DM, Howley PM. Fields Virology. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott:Williams & Wilkins;2007.

  26. Sugioka T, Kubota Y, Wakayama K, Kimura S. Severe steroid-resistant thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult. Intern Med. 2012;51(13):1747-50.

  27. DiMaggio D, Anderson A, Bussel JB. Cytomegalovirus can make immune thrombocytopenic purpura refractory. Br J Haematol. 2009 Jun;146(1):104-12.

  28. Varani S, Landini MP. Cytomegalovirus-induced immunopathology and its clinical consequences. Herpes viridae. 2011;2(1):6.

  29. Miyahara M, Shimamoto Y, Yamada H, Shibata K, Matsuzaki M, Ono K. Cytomegalovirus-associated myelodysplasia and thrombocytopenia in an immunocompetent adult. Ann Hematol. 1997 Feb;74(2):99-101.

  30. Tilden W, Valliani S. Severe thrombocytopenia and recurrent epistaxis associated with primary Epstein-Barr virus infection. BMJ Case Rep. 2015 Apr 9;2015. pii: bcr2014208018. doi: 10.1136/bcr-2014-208018.

  31. Dohno S, Maeda A, Ishiura Y, Sato T, Fujieda M, Wakiguchi H. Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants. Pediatr Int. 2010 Aug;52(4):536-40.

  32. Wu Z, Zhou J, Wei X, Wang X, Li Y, Peng B, et al. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in immune thrombocytopenia. Hematology. 2013 Sep;18(5):295-9.

  33. Bober G, Krawczyk-Kulis M, Kopera M, Holowiecki J. Severe thrombocytopenia associated with simultaneous cytomegalovirus and Epstein-barr virus infection in an immunocompetence patient. Pol Arch Med Wewn. 2003 Jun;109(6):623-7.

  34. Saeed M, Dabbagh O, Al-Muhaizae M, Dhalaan H, Chedrawi A. Acute disseminated encephalomyelitis and thrombocytopenia following Epstein-Barr virus infection. J Coll Physicians Surg Pak. 2014 Nov;24 Suppl 3:S216-8.




2020     |     www.medigraphic.com