Alteration of the inflammatory activity regulated by TH1-TH2 in asthma

Imelda Martínez-Ramírez; Alejandro Avilés-Salas; Héctor Nava-Reyes; María del Pilar Ramos-Godínez; Guillermo Carvajal-Sandoval; Pedro Zamudio-Cortés; Elías Parra-Hernández

2006, Number 2

Rev Inst Nal Enf Resp Mex 2006; 19 (2)

Alteration of the inflammatory activity regulated by T_H1-T_H2 in asthma

Martínez-Ramírez I, Avilés-Salas A, Nava-Reyes H, Ramos-Godínez MP, Carvajal-Sandoval G, Zamudio-Cortés P, Parra-Hernández E

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Language: Spanish
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ABSTRACT

Asthma affects between 100 and 150 million people around the globe. Currently, it is a disease that can be controlled by diverse therapeutic approaches; unfortunately, it cannot be cured. In many countries asthma is one of the most expensive and frequent diseases for the healthcare systems. Therefore, effective preventive strategies are greatly needed to reduce individual morbidity, mortality and economic burdens. This requires, among others, a detailed knowledge of the immunological and physiological mechanisms involved in asthma. This review synthesizes our understanding about the inflammation of T_H2-mediated asthma and discusses the origin of CD4+ T_H2 cells and the role of T_H2 cytokines in producing and maintaining airway inflammation in asthma.

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