2019, Number 12
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Revista Médica Sinergia 2019; 4 (12)
Update of Brugada syndrome
Phillips MÓ
Language: Spanish
References: 15
Page: 313
PDF size: 141.60 Kb.
ABSTRACT
Brugada syndrome, refers to a primary channelopathy, characterized by an
electrocardiographic pattern that in the right precordial leads and increases
the probability of developing a ventricular arrhythmia or an episode of
sudden cardiac death in a structurally normal heart. Brugada syndrome
primarily affects sodium channels through mutations in the SCN5A gene;
however, new mutations that affect calcium and potassium channels have
been discovered. Most patients with the Syndrome are asymptomatic,
however, the person can debut with a major cardiac episode (sudden death
or ventricular fibrillation) which makes this a life-threatening condition,
forcing health professionals to anticipate these events, stratifying the risk in
an appropriate manner. The cornerstone in the management of Brugada
syndrome remains the implantation of an ICD, however, new
pharmacological therapies continue to be developed however they need to
be proven.
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