2019, Number 2
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CorSalud 2019; 11 (2)
Ventricular repolarization in cancer therapy
Dorantes SM, Bazán MM
Language: Spanish
References: 16
Page: 146-152
PDF size: 731.58 Kb.
ABSTRACT
Ventricular depolarization and repolarization processes are discussed, including
their differences and heterogeneity both in patients with a healthy/sick heart, a
matter of ranges. Measurements expressing the characteristics of ventricular repolarization are analyzed: the QT interval and other even more reliable measurements such as the TPEAK-TEND interval, its dispersion and others. We emphasize on
the existence of the long QT syndrome (and sign) and the three basic processes of
arrhythmogenesis: heterogeneity, alternation and dispersion, with differences in
action potentials in the three zones of the ventricular myocardium. The risk factors
of long QT (common in this therapy) and ventricular arrhythmias (especially torsades de pointes, extremely rare in these cases) are highlighted. The need to assess clinical and electrical features, comorbidities, aggregate conflicts, and management of these patients is also discussed.
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