Cervigón GI, Sandín SS, Pérez HC, Bahillo MC, Vélez PC, García AD

Language: Spanish
References: 31
Page: 120-126
PDF size: 406.56 Kb.

ABSTRACT

DRESS síndrome is a severe drug reaction characterised by rash, fever, lymph nodes enlargement, hematologic abnormalities (eosinophilia, atipical lymphocytes) and internal organ involvement.
Aromatic anticonvulsivants and sulphonamides are the most common drugs associated with this clinical entity.
The diagnosis is established by the drug exposition, the clinical and laboratory features and the differential diagnosis with another diseases.
The therapeutic management includes the prompt withdrawal of the offending drug, the supportive therapy and the prevention of sepsis. The use of systemic corticosteroids remains controversial.
We repport a sulphonamides DRESS syndrome with severe multiorganic involvement. Clinical and analytic improvement has been obtained after systemic corticotherapy. We suggest their use when internal organs are severely affected.

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