2019, Number 11
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Ginecol Obstet Mex 2019; 87 (11)
EXIT (Ex-Utero Intrapartum Treatment) as a treatment option in fetuses with a high risk of death: a systematic review
Novoa RH, Quintana W, Ventura W
Language: Spanish
References: 83
Page: 769-780
PDF size: 401.89 Kb.
ABSTRACT
Objectives: To describe the characteristics of the patients, the surgical technique and
maternal and fetal complications of the EXIT (Ex-Utero Intrapartum Treatment) surgery
that do not include oral or cervical tumors.
Methodology: Systematic review of the literature that included searches in MEDLINE,
EMBASE, Cochrane Library and LILACS until September 2018 of all reports or
case series of EXIT surgery. Two authors made the selection, evaluation and extraction
of data. A descriptive analysis was then carried out.
Resultados: We included 71 full text study reports that included 242 cases of EXIT surgery.
The most frequent indication was the management of fetal airway in diaphragmatic
hernia (92%). EXIT surgery was performed on average at 34.4 weeks of gestation. The
access to ensure the fetal airway was 77% through orotracheal intubation. No maternal
deaths were reported, and overall perinatal survival was 77%.
Conclusions: EXIT surgery is a safe procedure for the fetus and for the mother and
has different indications, the most frequent was endotracheal balloon removal in the
treatment of diaphragmatic hernia.
REFERENCES
Cruz-Martínez R, y col. Técnica EXIT (Ex Utero Intrapartum Treatment): indicaciones, limitaciones, riesgos y evolución a la técnica de intubación traqueal fetal endoscópica (FETI). Ginecol Obstet Mex. 2015;83(1).
Bouchard S, et al. The EXIT procedure: experience and outcome in 31 cases. J Pediatr Surg. 2002;37(3):418-26. https://doi.org/10.1053/jpsu.2002.30839
Moldenhauer JS. Ex Utero Intrapartum Therapy. Seminars in pediatric surgery. 2013;22(1):44-9.
Abraham RJ, et al. A review of the EXIT (ex utero intrapartum treatment) procedure. Journal of obstetrics and gynaecology : Journal Obstetrics and Gynaecology. 2010; 30 (1): 1-5. https://doi.org/10.3109/01443610903281656
Harrison MR, et al. Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg. 1996; 31 (10): 1339-48. https://doi.org/10.1016/S0022-3468(96)90824-6
Taghavi K, Beasley S. The ex utero intrapartum treatment (EXIT) procedure: application of a new therapeutic paradigm. Journal of Paediatrics and Child Health. 2013; 49 (9): E420-7. https://doi.org/10.1111/jpc.12223
Laveriano WV, et al. Intubación endotraqueal intraparto en un feto con hernia diafragmática. A propósito de la primera cirugía fetal EXIT (ex-utero intrapartum treatment) en el Perú. Revista Peruana de Ginecología y Obstetricia. 2016; 61 (4): 417-21.
Gaiser RR, et al. Anesthetic management of cesarean delivery complicated by ex utero intrapartum treatment of the fetus. Anesthesia and Analgesia. 1997;84(5):1150-3.
Mychaliska GB, et al. Operating on placental support: the ex utero intrapartum treatment procedure. J Pediatr Surg. 1997; 32 (2): 227-31. https://doi.org/10.1016/S0022- 3468(97)90184-6
DeCou JM, et al. Successful ex utero intrapartum treatment (EXIT) procedure for congenital high airway obstruction syndrome (CHAOS) owing to laryngeal atresia. J Pediatr Surg. 1998; 33 (10): 1563-5. https://doi.org/10.1016/ S0022-3468(98)90500-0
Bui TH, et al. Successful EXIT (ex utero intrapartum treatment) procedure in a fetus diagnosed prenatally with congenital high-airway obstruction syndrome due to laryngeal atresia. Eur J Pediatr Surg. 2000; 10 (5): 328-33. doi: 10.1055/s-2008-1072385
Crombleholme TM, et al. Salvage of a fetus with congenital high airway obstruction syndrome by ex utero intrapartum treatment (EXIT) procedure. Fetal Diagnosis and Therapy. 2000; 15 (5): 280-2. https://doi.org/10.1159/000021022
Prontera W, et al Ex utero intrapartum treatment (EXIT) of severe fetal hydrothorax. Archives of disease in childhood Fetal and neonatal edition. ADC Fetal and Neonatal. 2002;86(1):F58-60. http://dx.doi.org/10.1136/ fn.86.1.F58
Russell MW, Gomez C, Nugent C, Christiansen J. Large fetal pulmonary arteriovenous fistula: impact on pulmonary development. J Pediatric Cardiology. 2002;23(4):454-7. https://doi.org/10.1007/s00246-002-0127-2
Hedrick HL. Ex utero intrapartum therapy. Seminars in Pediatric Surgery. 2003; 12 (3): 190-5. https://doi. org/10.1016/S1055-8586(03)00026-X
Lim FY, et al. Congenital high airway obstruction syndrome: natural history and management. J Pediatr Surg. 2003; 38 (6): 940-5. https://doi.org/10.1016/S0022-3468(03)00128- 3
Oepkes D, et al. Congenital high airway obstruction syndrome successfully managed with ex-utero intrapartum treatment. Ultrasound Obstet Gynecol. 2003;22(4):437-9. https://doi.org/10.1002/uog.899
Rosen MA, et al. Nitroglycerin for fetal surgery: fetoscopy and ex utero intrapartum treatment procedure with malignant hyperthermia precautions. Anesthesia & Analgesia. 2003;96(3):698-700. doi: 10.1213/01. ANE.0000049686.20464.3B
Baker PA, et al. Airway management during an EXIT procedure for a fetus with dysgnathia complex. Paediatric Anaesthesia. 2004;14(9):781-6. https://doi.org/10.1111/ j.1460-9592.2004.01284.x
Dahlgren G, et al. Four cases of the ex utero intrapartum treatment (EXIT) procedure: anesthetic implications. Int J Obstet Anesth. 2004;13(3):178-82. https://doi. org/10.1016/j.ijoa.2004.01.007
Hirose S, et al. The ex utero intrapartum treatment procedure: Looking back at the EXIT. J Pediatr Surg. 2004;39(3):375-80. https://doi.org/10.1016/j.jpedsurg. 2003.11.011
22. Kanamori Y, et al. A case of laryngeal atresia (congenital high airway obstruction syndrome) with chromosome 5p deletion syndrome rescued by ex utero intrapartum treatment. J Pediatr Surg. 2004; 39 (1): E25-8. https://doi. org/10.1016/j.jpedsurg.2003.09.041
Parry AJ, et al. Median sternotomy as an exit procedure in a child with massive pericardial tumor. J Pediatr Surg. 2004; 39 (9): 1408-10. https://doi.org/10.1016/j.jpedsurg. 2004.05.025
Chang YL, et al . Congenital chylothorax in three siblings. AJOG. 2005;192(6):2065-6. https://doi.org/10.1016/j. ajog.2004.09.012
Chu GM, et al. Ex-utero intrapartum treatment: a controlled approach to the management of anticipated airway problems in the newborn. Hong Kong Med J 2006; 12 (5): 381-4.
Kohl T, et al. Fetoscopic and ultrasound-guided decompression of the fetal trachea in a human fetus with Fraser syndrome and congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia. Ultrasound in obstetrics & Gynecology. 2006;27(1):84-8. https://doi. org/10.1002/uog.1974
Otteson TD, et al. The Ex Utero Intrapartum Treatment (EXIT) procedure: new challenges. Arch Otolaryngol Head Neck Surg. 2006;132(6):686-689. doi:10.1001/archotol. 132.6.686
Colnaghi M, et al. Prenatal diagnosis and postnatal management of congenital laryngeal atresia in a preterm infant. Ultrasound Obstet Gynecol. 2007; 29 (5): 583-5. https:// doi.org/10.1002/uog.3978
George RB, et al. Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure. Can J Anesth 2007; 54 (3): 218-22. https://doi.org/10.1007/BF03022643
Kern C, et al. Ex utero intrapartum treatment (EXIT), a resuscitation option for intra-thoracic foetal pathologies. Swiss Medical Weekly. 2007; 137 (19-20): 279-85.
Kunisaki SM, et al. Ex utero intrapartum treatment with extracorporeal membrane oxygenation for severe congenital diaphragmatic hernia. J Pediatr Surg. 2007;42(1):98-106. https://doi.org/10.1016/j.jpedsurg.2006.09.009
Saura L, et al. Impact of fetal intervention on postnatal management of congenital diaphragmatic hernia. Eur J Pediatr Surg. 2007;17(6):404-7. doi: 10.1055/s-2007- 989275
Shimabukuro F, et al. A case of congenital high airway obstruction syndrome managed by ex utero intrapartum treatment: case report and review of the literature. Amer J Perinatol. 2007; 24 (3): 197-201. doi: 10.1055/s-2007- 972928
Steiner H, et al. Ex-Utero Intrapartum Treatment (EXIT) in a giant case of Congenital Cystic Adenomatoid Malformation (CCAM) of the lung. Ultraschall in der Med. 2007; 28 (6): 626-28.doi: 10.1055/s-2007-963347
Umekawa T, et al. A case of agnathia-otocephaly complex assessed prenatally for ex utero intrapartum treatment (EXIT) by three-dimensional ultrasonography. Prenatal Diagnosis. 2007;27(7):679-81. https://doi.org/10.1002/ pd.1754
Benonis JG, Habib AS. Ex utero intrapartum treatment procedure in a patient with arthrogryposis multiplex congenita, using continuous spinal anesthesia and intravenous nitroglycerin for uterine relaxation. Int J Obstet Anesth. 2008;17(1):53-6. https://doi.org/10.1016/j. ijoa.2007.01.007
Chang LC, Kuczkowski KM. The ex utero intrapartum treatment procedure: anesthetic considerations. Archives of gynecology and obstetrics. 2008;277(1):83-5. https:// doi.org/10.1007/s00404-007-0402-9
Guimaraes CV, et al. Prenatal MRI findings of fetuses with congenital high airway obstruction sequence. Korean Journal of Radiology. 2009; 10 (2): 129-34. https://doi. org/10.3348/kjr.2009.10.2.129
Henry PY, et al. Extrauterine Intrapartum Treatment (EXIT) in bilateral primary fetal hydrothorax. Indian journal of pediatrics. 2009;76(1):99-101. https://doi.org/10.1007/ s12098-009-0038-9
Kohl T, et al. Percutaneous fetoscopic laser decompression of congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia via a single trocar--current technical constraints and potential solutions for future interventions. Fetal Diagnosis and Therapy. 2009;25(1):67-71. https://doi. org/10.1159/000200017
Morris LM, Lim FY, Crombleholme TM. Ex utero intrapartum treatment procedure: a peripartum management strategy in particularly challenging cases. J Pediatrics. 2009; 154 1): 126-31.e3. https://doi.org/10.1016/j.jpeds.2008.09.044
Morris LM, et al. Severe micrognathia: indications for EXIT-to-Airway. Fetal Diagn Ther. 2009;26(3):162-6. doi: 10.1159/000240162)
Mychaliska GB, et al. Giant pulmonary sequestration: the rare case requiring the EXIT procedure with resection and ECMO. Fetal Diagnosis and Therapy. 2009; 25 (1): 163-6. https://doi.org/10.1159/000209202
Vaikunth SS, et al. Congenital high airway obstruction syndrome due to complete tracheal agenesis: an accident of nature with clues for tracheal development and lessons in management. Fetal Diagnosis and Therapy. 2009;26(2):93- 7. https://doi.org/10.1159/000242454
Antinolo G, et al. Diagnosis and management of fetal intrapericardial Morgagni diaphragmatic hernia with massive pericardial effussion. J Pediatr Surg. 2010; 45 (2): 424-6. https://doi.org/10.1016/j.jpedsurg.2009.11.009
Berrington JE, et al. Emergency EXIT for preterm labour after FETO. Archives of Disease in Childhood Fetal and Neonatal edition. 2010;95(5):F376-7. http://dx.doi. org/10.1136/adc.2009.177303
Botto HA, Boailchuk. Tratamiento extrauterino intraparto: manejo del recién nacido con síndrome de obstrucción congénita de la vía aérea superior: informe de un caso. Arch Argent Pediatr. 2010;108(4):e92-e5.
Fink RJ, et al. Remifentanil for fetal immobilization and analgesia during the ex utero intrapartum treatment procedure under combined spinal-epidural anaesthesia. BJA. 2011; 106 (6): 851-5. https://doi.org/10.1093/bja/aer097
Hamid-Sowinska A, et al. Congenital high airway obstruction syndrome. Neuro Endocrinology Letters. 2011; 32 (5): 623-6.
Ioscovich A, et al. Remifentanil-nitroglycerin combination as an anesthetic support for ex utero intrapartum treatment (EXIT) procedure. J clinical anesthesia. 2011;23(2):142-4. https://doi.org/10.1016/j.jclinane.2009.12.014
Lazar DA, et al. Fetal lung interstitial tumor: a cause of late gestation fetal hydrops. J Pediatr Surg. 2011; 46 (6): 1263-6. https://doi.org/10.1016/j.jpedsurg.2011.02.056
Miwa I, et al. Congenital high airway obstruction syndrome in the breech presentation managed by ex utero intrapartum treatment procedure after intraoperative external cephalic version. J Obstet Gynaecol Research. 2012; 38 (5): 854-7. https://doi.org/10.1111/j.1447-0756.2011.01801.x
Ruano R, et al. A randomized controlled trial of fetal endoscopic tracheal occlusion versus postnatal management of severe isolated congenital diaphragmatic hernia. Ultrasound in Obstetrics & Gynecology. 2012;39(1):20-7. https://doi.org/10.1002/uog.10142
Saadai P, et al. Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome. J Pediatr Surg. 2012;47(6):1095-100. https://doi.org/10.1016/j. jpedsurg.2012.03.015
Stoffan AP, et al. Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change outcomes for high-risk patients with congenital diaphragmatic hernia? J Pediatr Surg. 2012; 47 (6): 1053-7. https://doi.org/10.1016/j.jpedsurg.2012.03.004
Cass DL, et al. EXIT-to-resection for fetuses with large lung masses and persistent mediastinal compression near birth. J Pediatr Surg. 2013; 48 (1): 138-44. https://doi. org/10.1016/j.jpedsurg.2012.10.067
Coleman AM, et al. Tracheal agenesis with tracheoesophageal fistulae: fetal MRI diagnosis with confirmation by ultrasound during an ex utero intrapartum therapy (EXIT) delivery and postdelivery MRI. Pediatric Radiology. 2013; 43 (10): 1385-90. https://doi.org/10.1007/s00247- 013-2679-0.
Osborn AJ, et al. Multidisciplinary perinatal management of the compromised airway on placental support: lessons learned. Prenatal Diagnosis. 2013; 33 (11): 1080-7. https:// doi.org/10.1002/pd.4200
Calvo-Garcia MA, et al. Congenital peribronchial myofibroblastic tumor: prenatal imaging clues to differentiate from other fetal chest lesions. Pediatric Radiology. 2014; 44 (4): 479-83. https://doi.org/10.1007/s00247-013-2817-8
Chatterjee D, et al. Ex utero intrapartum treatment to resection of a bronchogenic cyst causing airway compression. Fetal Diagnosis and Therapy. 2014; 35 (2): 137-40. https:// doi.org/10.1159/000355661
DaValle B, et al. Ex utero intrapartum treatment of fetal micrognathia. Military Medicine. 2014; 179 (6): e705-11. https://doi.org/10.7205/MILMED-D-13-00466
Ogasawara K, et al. Ex utero intrapartum treatment for an infant with cerebro-costo-mandibular syndrome. Pediatrics International. 2014; 56 (4): 613-5. https://doi.org/10.1111/ ped.12299
Pivetti V, et al. Cesarean section plus delayed cord clamping approach in the perinatal management of congenital high airway obstruction syndrome (CHAOS): a case report. Journal of Neonatal-Perinatal Medicine. 2014; 7 (3): 237-9. doi: 10.3233/NPM-14814006
Suenaga M, et al. Successful ex utero intrapartum treatment procedure for prenatally diagnosed severe micrognathia: a case report. Obstetrics & Gynecology. 2014; 40 (8): 2005-9. https://doi.org/10.1111/jog.12423
6Basta MN, et al. Total Airway Reconstruction in the Neonate: Combined Mandibular Distraction and Slide Tracheoplasty for Multiple Level Airway Obstruction. Journal of Craniofacial Surgery. 2015; 26 (8): e788-91. doi: 10.1097/ SCS.0000000000002145
Peng E, et al Ex-utero intrapartum treatment as a novel bridging strategy to surgery in hypoplastic left heart syndrome with intact atrial septum-cross-circulation revisited. JTCVS. 2015; 149 (3): 935-7. https://doi.org/10.1016/j. jtcvs.2014.11.053
Braden A, et al. Anesthetic management of an ex utero intrapartum treatment procedure: a novel balanced approach. J Clin Anesth. 2016; 31: 60-3. https://doi. org/10.1016/j.jclinane.2015.12.010
Kanasugi T, et al. Successful ultrasound-guided intraoperative external cephalic version of fetus in breech presentation immediately before ex-utero intrapartum treatment (EXIT) procedure. Ultrasound in Obstetrics & Gynecology. 2016;47(5):653-5. https://doi.org/10.1002/uog.15763
Lin EE, et al. Anesthetic Management of 65 Cases of Ex Utero Intrapartum Therapy: A 13-Year Single-Center Experience. Anesthesia & Analgesia. 2016; 123 (2): 411-7. https://doi.org/10.1213/ANE.0000000000001385
Rychik J, et al. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. AJOG. 2016; 215 (6): 780.e1-.e7. https://doi.org/10.1016/j. ajog.2016.08.010
Cuneo BF, et al. Ex utero Intrapartum Treatment to Ventricular Pacing: A Novel Delivery Strategy for Complete Atrioventricular Block with Severe Bradycardia. Fetal Diagn Ther. 2017; 42: 311-14. https://doi.org/10.1159/000475815
Hung TH, et al. Ex utero intrapartum treatment for extremely low birth-weight neonates requiring resuscitation at birth. Taiwan J Obstet Gynecol 2017; 56 (4): 561-3. doi: 10.1016/j.tjog.2017.07.001.
Koch S, et al. [EXIT - A Possible Intervention for New- and Earlyborn Babies with Severe Hydrops Fetalis and Hydrothoraces on Both Sides]. Zeitschrift fur Geburtshilfe und Neonatologie. 2017. 10.1055/s-0043-117419
Stoffan AP, et al. Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change morbidity outcomes for high-risk congenital diaphragmatic hernia survivors? J Pediatr Surg. 2012; 47: 1053-57. https://doi.org/10.1016/j.jpedsurg.2012.03.004
Zhuang J, et al. Ex utero Intrapartum Treatment for the Pericardial Effusion Drain of a Fetal Cardiac Tumor. Chin Med J (Engl). 2017;130 (11): 1381-2. 10.4103/0366-6999.206342
Kunisaki SM, et al. Ex utero intrapartum treatment with placement on extracorporeal membrane oxygenation for fetal thoracic masses. J Pediatr Surg. 2007; 42 (2): 420-5. https://doi.org/10.1016/j.jpedsurg.2006.10.035
Liechty KW. Ex-utero intrapartum therapy. Seminars in Fetal & Neonatal Medicine. 2010; 15 (1): 34-9. https://doi. org/10.1016/j.siny.2009.05.007
Jani JC, et al. Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion. Ultrasound in Obstetrics and Gynecology. 2009; 34 (3): 304-10. https://doi. org/10.1002/uog.6450
Cass DL, et al. Prenatal diagnosis and outcome of fetal lung masses. J Pediatr Surg. 2011; 46 (2): 292-8. https:// doi.org/10.1016/j.jpedsurg.2010.11.004
Ngamprasertwong P, et al. Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure. Int Anesthesiol Clin. 2012; 50 (4): 26-40. 10.1097/ AIA.0b013e31826df966
Hoagland MA, et al. Anesthesia for fetal surgery. Pediatr Anaesth. 2017;27(4):346-57. doi: 10.1111/pan.13109.
Liechty KW, et al. Intrapartum airway management for giant fetal neck masses: the EXIT (ex utero intrapartum treatment) procedure. Am J Obstet Gynecol. 1997;177(4):870-4. https://doi.org/10.1016/S0002- 9378(97)70285-0
Noah MM, et al. Short-term maternal outcomes that are associated with the EXIT procedure, as compared with cesarean delivery. Am J Obstet Gynecol. 2002;186(4):773-7. https://doi.org/10.1067/mob.2002.112249