2019, Number 5
<< Back Next >>
Med Int Mex 2019; 35 (5)
Deficiency of vitamin D in elderly adults with hip fracture
Herrera-Vázquez A, Avendaño-Vázquez E, Torres-Alarcón CG
Language: Spanish
References: 41
Page: 669-675
PDF size: 365.00 Kb.
ABSTRACT
Objective: To know the prevalence of vitamin D deficiency in older adults with and
without hip fracture in a third level hospital.
Material and Method: An observational, descriptive, retrospective and crosssectional
study was conducted in elderly patients from August 1st 2016 to August 1st 2017.
For their analysis, they were divided into two groups, one group with a hip fracture and
the other without a fracture history. Demographic data, levels of 25-hydroxyvitamin-D
[25(OH)D] and PTH were collected. Vitamin D deficiency was defined according to
Holick’s classification.
Results: There were included 58 patients, each group with 29. The levels of 25(OH)
D were, on average, 18.24 ± 7.8 ng/mL in all patients, with differences between
the groups of fractured
vs non-fractured: 14.83 ± 5.28 ng/mL vs 21.66 ± 7.45 ng/
mL, respectively; p ‹ 0.001. The prevalence of vitamin D deficiency was 63.7%,
being higher in the fractured group compared to those without this background:
86.2%
vs 41.4%.
Conclusions: Deficiency of vitamin D is high in the population of elderly adults
and its frequency is increased with age.
REFERENCES
Bikle D. Vitamin D: Production, metabolism, and mechanisms of action. In: Endotext MDText. com, Inc.; 2017.
Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88(2):491S-499S. http://dx.doi. org/10.1093/ajcn/88.2.491S.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96(7):1911-1930. doi: 10.1210/ jc.2011-0385.
American Geriatrics Society. Recommendations abstracted from the american geriatrics society consensus statement on vitamin D for prevention of falls and their consequences. J Am Geriatr Soc 2013;62(1):147-152. doi: 10.1111/ jgs.12631.
Sai AJ, Walters RW, Fang X, Gallagher JC. Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab 2011;96(3):E436-E446. doi: 10.1210/jc.2010-1886.
Skrobot A, Demkow U, Wachowska M. Immunomodulatory role of vitamin D: A review. In: Springer, ed. Advances in Experimental Medicine and Biology. New York, NY; 2018.
Holick MF, Matsuoka L, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet 1989;334(8671):1104-1105. DOI: 10.1016/s0140-6736(89)91124-0 5. Tinetti ME, Williams TF, Mayewski R. Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 1986;80(3):429-434. DOI: 10.1016/0002- 9343(86)90717-5. 6. Hewston P, Deshpande N. Falls and balance impairments in older adults with type 2 diabetes: Thinking beyond diabetic peripheral neuropathy. Can J Diabetes 2016;40(1):6-9. doi: 10.1016/j.jcjd.2015.08.005. 7. Bruce D, Hunter M, Peters K, Davis T, Davis W. Fear of falling is common in patients with type 2 diabetes and is associated with increased risk of falls. Age Ageing 2015;44(4):687- 690. doi: 10.1093/ageing/afv024.
Pijpers E, Ferreira I, de Jongh RT, Deeg DJ, Lips P, Stehouwer CD, et al. Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam. Age Ageing 2012;41(3):358-365. doi: 10.1093/ ageing/afr145.
Yang Y, Hu X, Zhang Q, Zou R. Diabetes mellitus and risk of falls in older adults: a systematic review and metaanalysis. Age Ageing 2016;45(6):761-767. DOI: 10.1093/ ageing/afw140.
Rajpathak SN, Fu C, Brodovicz KG, Engel SS, Lapane K. Sulfonylurea use and risk of hip fractures among elderly men and women with type 2 diabetes. Drugs Aging 2015;32(4):321-327. doi: 10.1007/s40266-015-0254-0.
Berlie HD, Garwood CL. Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly. Ann Pharmacother 2010;44(4):712-717. doi: 10.1345/aph.1M551.
Miller DK, Lui LY, Perry HM 3rd, Kaiser FE, Morley JE. Reported and measured physical functioning in older inner-city diabetic African Americans. J Gerontol A Biol Sci Med Sci 1999;54(5):M230-M236. DOI: 10.1093/ gerona/54.5.m230.
Chiba Y, Kimbara Y, Kodera R, Tsuboi Y, Sato K, Tamura Y, et al. Risk factors associated with falls in elderly patients with type 2 diabetes. J Diabetes Complications 2015;29(7):898- 902. doi: 10.1016/j.jdiacomp.2015.05.016.
Lim JY, Jung SH, Kim WS, Paik NJ. Incidence and risk factors of poststroke falls after discharge from inpatient rehabilitation. PM R 2012;4(12):945-953. doi: 10.1016/j. pmrj.2012.07.005.
Richardson JK, Ashton-Miller JA. Peripheral neuropathy: an often-overlooked cause of falls in the elderly. Postgrad Med 1996;99(6):161-172.
Al-Momani M, Al-Momani F, Alghadir AH, Alharethy S, Gabr SA. Factors related to gait and balance deficits in older adults. Clin Interv Aging 2016;11:1043-1049. DOI https:// doi.org/10.2147/CIA.S112282.
Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor LB. Diabetes, vestibular dysfunction, and falls: analyses from the National Health and Nutrition Examination Survey. Otol Neurotol 2010;31(9):1445-1450. doi: 10.1097/ MAO.0b013e3181f2f035.
Schwartz AV, Vittinghoff E, Sellmeyer DE, Feingold KR, De Rekeneire N, Strotmeyer ES, et al. Diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care 2008;31(3):391-396. doi: 10.2337/dc07-1152.
Runzer-Colmenares FM, Samper-Ternent R, Snih S Al, Ottenbacher KJ, Parodi JF, Wong R, et al. Prevalence and factors Associated with frailty among Peruvian older adults. Arch Gerontol Geriatr 2014;58(1):1–11. doi: 10.1016/j. archger.2013.07.005.
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with selfreported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49(2):M85-M94. DOI: 10.1093/geronj/49.2.m85.
Washburn RA, Smith KW, Jette AM, Janney CA. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 1993;46(2):153-162.
Rothman MD, Leo‐Summers L, Gill TM. Prognostic significance of potential frailty criteria. J American Geriatr Soc 2008;56(12):2211-2216. doi: 10.1111/j.1532- 5415.2008.02008.x.
Richardson JK, Ching C, Hurvitz EA. The relationship between electromyographically documented peripheral neuropathy and falls. J American Geriatr Soc 1992;40(10):1008- 1012. DOI: 10.1111/j.1532-5415.1992.tb04477.x
Canbek J, Fulk G, Nof L, Echternach J. Test-retest reliability and construct validity of the Tinetti performanceoriented mobility assessment in people with stroke. J Neurol Phys Ther 2013;37(1):14-19. doi: 10.1097/ NPT.0b013e318283ffcc.
Singh R, Kishore L, Kaur N. Diabetic peripheral neuropathy: current perspective and future directions. Pharmacol Res 2014;80:21-35. doi: 10.1016/j.phrs.2013.12.005.
Chiles NS, Phillips CL, Volpato S, Bandinelli S, Ferrucci L, Guralnik JM, et al. Diabetes, peripheral neuropathy, and lower-extremity function. J Diabetes Complications 2014;28(1):91-95. doi: 10.1016/j.jdiacomp.2013.08.007.
Strotmeyer ES, De Rekeneire N, Schwartz AV, Faulkner KA, Resnick HE, Goodpaster BH, et al. The Relationship of Reduced Peripheral Nerve Function and Diabetes to Physical Performance in Older White and Black Adults: The Health, Aging and Body Composition Study. Diabetes Care 2008;31(9):1767-1772. doi: 10.2337/dc08-0433.
Hall RK, Landerman LR, O’Hare AM, Anderson RA, Colón- Emeric CS. Chronic kidney disease and recurrent falls in nursing home residents: A retrospective cohort study. Geriatr Nurs 2015;36(2):136-141. doi: 10.1016/j.gerinurse. 2014.12.012.
López-Soto PJ, De Giorgi A, Senno E, Tiseo R, Ferraresi A, Canella C, et al. Renal disease and accidental falls: a review of published evidence. BMC Nephrol 2015;16(1):176.
López-Soto PJ, De Giorgi A, Senno E, Tiseo R, Ferraresi A, Canella C, et al. Renal disease and accidental falls: a review of published evidence. BMC Nephrol 2015;16(1):176.
Kwok T, Liddle J, Hastie IR. Postural hypotension and falls. Postgrad Med J 1995;71(835):278-280. doi: 10.1136/ pgmj.71.835.278.
Campbell AJ. Drug treatment as a cause of falls in old age. Drugs Aging 1991;1(4):289-302.
Deandrea S, Lucenteforte E, Bravi F, Foschi R, La Vecchia C, Negri E. Risk factors for falls in community-dwelling older people: A systematic review and meta-analysis. Epidemiology 2010;21(5):658-668. doi: 10.1097/ EDE.0b013e3181e89905.
Richardson K, Bennett K, Kenny RA. Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults. Age Ageing 2014;44(1):90-96. doi: 10.1093/ageing/afu141.
Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int 2012;12(3):425- 430. doi: 10.1111/j.1447-0594.2011.00783.x.
Pfortmueller CA, Lindner G, Exadaktylos AK. Reducing fall risk in the elderly: risk factors and fall prevention, a systematic review. Minerva Med 2014;105(4):275-81.
Munch T, Harrison SL, Barrett-Connor E, Lane NE, Nevitt MC, Schousboe JT, et al. Pain and falls and fractures in community- dwelling older men. Age Ageing 2015;44(6):973- 979. doi: 10.1093/ageing/afv125.
Welmer AK, Rizzuto D, Calderón-Larrañaga A, Johnell K. Sex differences in the association between pain and injurious falls in older adults: a population-based longitudinal study. Am J Epidemiol 2017;186(9):1049-1056. doi: 10.1093/ aje/kwx170.
Li W, Katzmarzyk PT, Horswell R, Zhang Y, Wang Y, Johnson J, et al. Body mass index and heart failure among patients with type 2 diabetes. Circ Heart Fail 2015;8(3):455-463. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001837.
Herrera-Rangel AB, Aranda-Moreno C, Mantilla-Ochoa T, Zainos-Saucedo L, Jáuregui-Renaud K. Influence of the body mass index on the occurrence of falls in patients with type 2 diabetes mellitus. Obes Res Clin Pract 2015;9(5):522-526. doi: 10.1016/j.orcp.2015.02.006.
Coutinho ES, Fletcher A, Bloch KV, Rodrigues LC. Risk factors for falls with severe fracture in elderly people living in a middle-income country: a case control study. BMC Geriatr 2008;8(1):21. doi: 10.1186/1471-2318-8-21.