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2019, Number 5

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Rev Fac Med UNAM 2019; 62 (5)

Sporotrichosis: the most frequent subcutaneous mycosis in Mexico

Zurabian R, Hernández HF

Language: Spanish
References: 29
Page: 48-55
PDF size: 264.22 Kb.


ABSTRACT

Sporotrichosis is a mycosis caused by fungal species that are part of the Sporothrix schenckii complex. Epidemiological and molecular studies have found only six species of the Sporothrix schenckii complex that cause infections in humans. Some species of this complex have a relevant zoonotic potential for transmission to humans, and some others only have phytopathogenic properties. It is considered the most frequent form of subcutaneous mycosis in Mexico. The main mechanism of infection a wound with loss of continuity of the skin followed by contamination with the fungus Sporothrix spp. The main clinical manifestations are lymphangitic sporotrichosis, fixed skin manifestation and disseminated manifestation. The most useful laboratory procedures to confirm the diagnosis are the cultivation of specimens such as exudate and tissue, as well as the histopathological study. The parasitic manifestation is represented by yeasts in the tissue or exudates. The most useful medications for its treatment are potassium iodide and itraconazole. Prevention is difficult; however, the use of protective equipment during work activities can help prevent this condition.


REFERENCES

  1. De Beer ZW, Duong TA, Wingfield MJ. The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship. Stud Mycol. 2016;83:165-91.

  2. Barros BLM, de Almeida Pae R, Oliveira Schubach A. Spo- rothrix schenckii and Sporotrichosis. Clin Microbiol Rev. 2011;24(4):633-54.

  3. Bonifaz A. Esporotricosis. En: Bonifaz Trujillo AJ (ed.). Micología Médica Básica. Forth Edition, McGraw-Hill Interamericana Editores, S.A. de C.V.;2012. p.p. 214-30.

  4. Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S. Global epidemiology of sporotrichosis. Med Micol. 2015;53:3-14.

  5. Vásquez-del-Mercado E, Arenas R, Padilla-Desgarenes C. Sporotrichosis. Clin Dermatol. 2012;30(4):437-43.

  6. Zhang N, Castlebury LA, Miller AN, Huhndorf SM, Schoch CL, Seifert KA, Rossman AY, Rogers JD, Kohlmeyer J, Volkmann-Kohlmeyer B, Sung GH. An overview of the systematics of the Sordariomycetes based on a four-gene phylogeny. Mycologia. 2006;98:1076-87.

  7. López-Romero E, María del Rocío Reyes-Montes MR, Pérez- Torres A, Ruiz-Baca E, Villagómez-Castro JC, Héctor M Mora-Montes HM, Flores-Carreón A, Toriello C. Sporothrix schenckii complex and sporotrichosis, an emerging health problema. Fut Microbiol. 2011;6(1):85-102.

  8. Orofino-Costa R, Macedo PM, Rodrigues AM, Bernardes- Engemann AR. Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. An Bras Dermatol. 2017;92(5):606-20.

  9. Lopes-Bezerra LM, Mora-Montes HM, Zang Y, Nino-Vega G, Rodrigues AM, Pires de Camargo Zde Hoog S. Sporotrichosis between 1928 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. Medical Micol. 2018;56:S126-43.

  10. Marimon R, Cano J, Gené J, Sutton D, Kawasaki M, Guarro J. Sporothrix brasiliensis, S. globosa, and S. mexicana. Three new Sporothrix species of clinical interest. J Clin Microbiol. 2007;45:3198-206.

  11. López Martínez R, Méndez Tovar LJ, Hernández Hernández F, Castañon Olivares LR. Micología Médica. Procedimientos para el diagnóstico de laboratorio. 3era ed. Trillas S.A. de C.V.; 2012.

  12. Garrison RG, Boyd KS, Mariat F. Ultrastructural studies of the mycelium-to yeast transformation of Sporothrix schenckii. J Bacteriol. 1975;124:959-68.

  13. Lloyd KO, Bitoon MA. 1971. Isolation and purification of a peptido-rhamnomannan from the yeast form of Sporothrix schenckii. Structural and immunochemical studies. J Immunol. 1971;107:663-71.

  14. Almeida-Paes R, Frases S, Fialho Monteiro PC, Gutierrez- Galhardo MC, Zancopé-Oliveira RM, Nosanchuk JD. Growth conditions influence melanization of Brazilian clinical Sporothrix schenckii isolates. Microbes Infect. 2009;11:554-62.

  15. Romero-Martinez R, Wheeler M, Guerrero-Plata A, Rico G, Torres-Guerrero H. Biosynthesis and functions of melanin in Sporothrix schenckii. Infect Immun. 2000;68:3696-703.

  16. Lima OC, Figueiredo CC, Pereira BA, Coelho MG, Morandi V, Lopes-Bezerra LM. Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins. Braz J Med Biol Res. 1999;32:651-57.

  17. Lima OC, Figueiredo CC, Previato JO, Mendonça-Previato L, Morandi V, Lopes Bezerra LM. Involvement of fungal cell wall components in adhesion of Sporothrix schenckii to human fibronectin. Infect Immun. 2001;69:6874-80.

  18. Ruiz-Baca E, Toriello C, Perez-Torres A, Sabanero-Lopez M, Villagomez-Castro JC, Lopez-Romero E. Isolation and some properties of a glycoprotein of 70 kDa (Gp70) from the cell wall of Sporothrix schenckii involved in fungal adherence to dermal extracellular matrix. Med Mycol. 2009;47:185-96.

  19. Torinuki W, Tagami H. Complement activation by Sporothrix schenckii. Arch. Dermatol Res. 1985;277:332-3.

  20. Scott EN, Muchmore HG, Fine DP. Activation of the alternative complement pathway by Sporothrix schenckii. Infect Immun. 1986;51:6-9.

  21. Goncalves AC, Ferreira LS, Manente FA, Gonçalves AC, Polesi MC, Batista-Duharte A, Carlos IZ. The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection. Immunol. 2017;151:154-66.

  22. Verdan FF, Faleiros JC, Ferreira LS, Monnazzi LG, Maia DC, Tansine A, Placeres MC, Carlos IZ, Santos-Junior RR. Dendritic cell are able to differentially recognize Sporothrix schenckii antigens and promote Th1/Th17 response in vitro. Immunobiol. 2012;217:788-94.

  23. Barros MB, Schubach AO, do Valle AC, Gutierrez Galhardo MC, Conceição-Silva F, Schubach TM, Reis RS, Wanke B, Marzochi KB, Conceição MJ. Cat-transmitted sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a series of cases. Clin Infect Dis. 2004;38:529-35.

  24. Barros MB, Schubach TM, Gutierrez Galhardo MC. Sporotrichosis: an emergent zoonosis in Rio de Janeiro. Mem Inst Oswaldo Cruz. 2001;96:777-9.

  25. Schubach TMP, Schubach A, Okamoto T, Barros MB, Figueiredo FB, Cuzzi T, Fialho-Monteiro PC, Reis RS, Perez MA, Wanke B. Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). J Am Vet Med Assoc. 2004;224:1623-29.

  26. Kauffman CA. Sporotrichosis. Clin Infect Dis. 1999;29:231-7.

  27. Barros MBL, Schubach AO, Schubach TM, Wanke B, Lambert- Passos SR. An epidemic of sporotrichosis in Rio de Janeiro, Brazil: epidemiological aspects of a series of cases. Epidemiol Infect. 2008;136:1192-6.

  28. Fernandes GF, dos Santos PO, Rodrigues AM, Sasaki AA, Burger E, de Camargo ZP. Characterization of virulence profile, protein secretion and immunogenicity of different Sporothrix schenckii sensu stricto isolates compared with S. globosa and S. brasiliensis species. Virulence. 2013;4: 241-9.

  29. Alba-Fierro CA, Pérez-Torres A, Toriello C, Pulido-Camarillo E, López-Romero E, Romo-Lozano Y, Gutiérrez- Sánchez G, Ruiz-Baca E. Immune response induced by an immunodominant 60 kDa glycoprotein of the cell wall of Sporothrix schenckii in two mice strains with experimental sporotrichosis. J Immunol Res. 2016;6525831.




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