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Federación Mexicana de Ginecología y Obstetricia, A.C.

2019, Number 09

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Ginecol Obstet Mex 2019; 87 (09)

Cut-off value in FSH levels as a prognostic factor for oocyte yield in IVF cycles with antagonist protocol

Guarneros-Valdovinos LR, Benítez-Castro KL, Carballo-Mondragón E, Kably-Ambe A

Language: Spanish
References: 15
Page: 594-599
PDF size: 303.36 Kb.


ABSTRACT

Background: Measurement of follicle-stimulating hormone (FSH) is used as a marker of ovarian reserve. The number of oocytes obtained is significantly lower among women with higher FSH levels.
Objective: To know the cut-off level of FSH and its prognostic value in the number of oocytes retrieved.
Methods: Retrospective study performed on patients in their first cycle of in vitro fertilization with an antagonist protocol. The patients were separated into two groups according to the basal FSH concentrations: group 1 FSH lower than 7 mIU / mL, group 2 with concentrations greater than 7 mIU / mL. Compared variables among groups were: age, total dose of gonadotropins, peak of estradiol, total number of oocytes retrieved, number of oocytes in metaphase II, number of embryos available for transfer, and the pregnancy rate.
Results: Group 1 included 927 women, while group 2 included 514 women. Age was lower in group 1 (34.3 vs. 35.3, p ‹0.05). In group 1 more oocytes were obtained (11.15 vs 8.26, p ‹0.05), as well as more mature oocytes (7.4 vs 5.3, p ‹0.05). There was no significant difference in pregnancy rates between both groups (27.98 vs. 28.92, p = 0.54).
Conclusions: A baseline FSH› 7 correlates significantly with obtaining fewer oocytes in IVF treatment cycles with antagonist protocols.


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