Morales MG, Ruiz ÁM, Aguirre SJ, Elizalde GJJ, Poblano MM, Martínez SJ

Language: Spanish
References: 18
Page: 57-64
PDF size: 158.52 Kb.

ABSTRACT

Introduction: Procalcitonin (PCT) has been used as a marker of infection in the intensive care unit.
Objective: Early identification of SIRS patients with infection by determination of circulating plasma concentrations of procalcitonin.
Design: Prospective study.
Setting: ICU of a private tertiary care hospital of Mexico City.
Patients: Thirty patients divided in two groups: A) 16 SIRS patients (mean age 60.4 ± 21.2 yrs) and B) 14 sepsis patients (mean age 68.6 ± 14.8 yrs) admitted to ICU during a six-month period.
Measurements and main results: Circulating plasma concentrations of procalcitonin were determined at admission and at 24, 48, 72 hours and thereafter every 48 hours (a total of six determinations). Level of PCT at admission was 0.46 ug•dL in SIRS patients and 1.9 ug•dL in sepsis patients (p = 0.03). APACHE II Scale was 10.6 ± 6.3 vs 14.1 ± 7 points (p = NS), ICU stay 14.5 ± 15 vs 10.3 ± 5.8 days (p = NS) and mortality rate 6.3% vs 21.4%, respectively.
Conclusion: Procalcitonin is a useful marker to discriminate SIRS and sepsis in critically ill patients.

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