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Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2019, Number 1-2

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Rev Mex Periodontol 2019; 10 (1-2)

Periodontitis association with Alzheimer's disease, Parkinson's disease and ischemic cerebrovascular event: literature review

Ruiz EJ, López DS, Espinosa CLF

Language: Spanish
References: 39
Page: 6-12
PDF size: 326.71 Kb.


ABSTRACT

Background: Periodontitis is considered a health problem around the world, besides the inflammatory issues which are mediated by pro and anti-inflammatory mediators during life, this disease has been associated with several systemic diseases where we can distinguish neurodegenerative as Alzheimer disease (AD), ischemic cerebrovascular event (EVC) and Parkinson’s disease (PkD); however, the associations between those diseases and periodontitis are still unclear. Objective: To identify the association risk and the different development mechanisms between periodontitis and AD, EVC, PkD through literature review of scientific papers previously reported. Material and methods: All articles were selected on PubMed NCBI database with a consecutive non-probabilistic sampling, using English and Spanish keywords as: ischemic stroke (enfermedad cerebro vascular isquémico), Alzheimer’s disease (enfermedad de Alzheimer), Parkinson’s disease (enfermedad de Parkinson), all these three related to periodontitis. The included articles were clinic studies with humans, comparative (two or more groups), prospective longitudinal, studies with results that confirm risk factors, and all studies published between January 2010 to December 2017. Results: From 21 articles included, 6 (28.5%) indicated that there is no risk between periodontitis and neurodegenerative diseases, 4 (19.04%) mentioned a slight risk and, finally, 11 (52.3%) reported a solid risk, most of them used clinical markers followed by pro-inflammatory and finally microbiological. Conclusions: Most of the reports included indicate that the EVC and AD present the alterations with the greatest associations with periodontitis than PD; however, other studies are necessary to determine the role of the severity and extent of periodontitis in these diseases.


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