medigraphic.com
ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2019, Number 3

<< Back Next >>

Acta Med Cent 2019; 13 (3)

Factores epigenéticos involucrados en el origen de defectos congénitos relacionados con la deficiencia materna de ácido fólico y otros micronutrientes

Taboada LN

Language: Spanish
References: 26
Page: 439-454
PDF size: 230.77 Kb.


ABSTRACT

Introduction: the sequencing of the human genome has been one of the most important achievements in the history of science. However, scientists around the world are beginning to realize that knowing the genetic information is not enough to understand the different phenotypic manifestations. The genome codes for a potential information, but the way in which the deoxynucleic acid sequence translates into a certain phenotype does not depend directly on the sequence itself, but on the interaction with environmental factors. This is when epigenetics plays its part. Objective: to provide updated information on the different epigenetic processes involved in the origin of some congenital defects related to folic acid deficiency. Method: the medical literature published in the last five years in Spanish and English was reviewed, Google Academic and PubMed search engines were used, the SciELO and Cochrane digital libraries were consulted, the Medline database was used and appropriate keywords were used. Development: there are different epigenetic mechanisms involved in the origin of congenital defects related to maternal deficiency of folic acid and other micronutrients. Conclusions: the fact that epigenetic alterations, in contrast to genetic changes such as mutations, are reversible has important implications for the implementation of strategies to prevent different congenital defects related to maternal deficiency of folic acid.


REFERENCES

  1. Taboada Lugo N. La evolución desde la perspectiva de la genética poblacional. En: Lardoeyt Ferrer R. Fundamentos de Genética Médica Poblacional [Internet]. La Habana: Ed Ciencias Médicas; 2016. p. 90-106. [citado 8 Ene 2018]. Disponible en: http://www.bvs.sld.cu/libros/fundamento_genetica/indice_p.htm

  2. Cavalli G, Paro R. Epigenetic inheritance of active chromatin after removal of the main transactivator. Science [Internet]. 1999 Oct [citado 8 Ene 2018];286(5441):955-958. Disponible en: http://science.sciencemag.org/content/286/5441/955/tab-pdf

  3. Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. Nature Rev Genetics [Internet]. 2012 Jan [citado 8 Ene 2018];13:97–109. Disponible en: https://www.nature.com/articles/nrg3142

  4. Taboada LN, Lardoeyt FR. Discapacidad intelectual: Aproximación a factores causales genéticos y epigenéticos. Rev Investig Inform Salud [Internet]. 2012 [citado 8 Ene 2018];7(18):45-52. Disponible en: http://saudepublica.bvs.br/pesquisa/resource/pt/cum-57350

  5. Novelle García M. Análisis de la influencia epigenética de los tratamientos de reproducción asistida en los resultados gestacionales y perinatales [tesis de doctorado]. Madrid: Universidad Autónoma de Madrid; 2015 [citado 8 Ene 2018]. Disponible en: https://repositorio.uam.es/bitstream/handle/10486/666365/novelle_%20garcia_monica.pdf?sequence=1

  6. García Robles R, Ayala Ramírez PA, Perdomo Velásquez SP. Epigenética: definición, bases moleculares e implicaciones en la salud y en la evolución humana. Rev Cienc Salud [Internet]. 2012 [citado 8 Ene 2018];10(1):59-71. Disponible en: https://www.redalyc.org/articulo.oa?id=56222455006

  7. Tollefsbol T. Handbook of epigenetics: the new molecular and medical genetics. 2nd ed. Oxford: Academic Press; 2011. p. 618. Disponible en: https://www.elsevier.com/books/handbook-of-epigenetics/tollefsbol/978-0-12-805388-1

  8. Canetti E. Epigenética: una explicación de las enfermedades hereditarias. Perinatol Reprod Hum [Internet]. 2003 [citado 8 Ene 2018];17(2):57-60. Disponible en: http://www.medigraphic.com/pdfs/inper/ip-2003/ip032a.pdf

  9. Zovkic IB, Meadows JP, Kaas GA, Sweatt JD. Interindividual variability in stress susceptibility: A role for epigenetic mechanisms in PTSD. Front Psychiatry [Internet]. 2013 Jun [citado 8 Ene 2018];4:60. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693073/

  10. 10.Tchasovnikarova IA, Kingston RE. Beyond the Histone Code: A Physical Map of Chromatin States. Mol Cell [Internet]. 2018 Jan [citado 8 Ene 2018];69(1):5-7. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29304334

  11. 11.Robinson DCL, Dilworth FJ. Epigenetic regulation of adult myogenesis. Curr Top Dev Biol [Internet]. 2018 [citado 8 Ene 2018];126:235-284. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29305001

  12. 12.Fukuto A, Ikura M, Ikura T, Sun J, Horikoshi Y, Shima H, et al. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites. Nucleus [Internet]. 2018 Jan [citado 8 Ene 2018];9(1):87-94. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29095668

  13. 13.Allis CD, Jenuwein T. The molecular hallmarks of epigenetic control. Nature Reviews Genetics [Internet]. 2016 Jun [citado 8 Ene 2018];17:487–500. Disponible en: https://www.nature.com/articles/nrg.2016.59

  14. 14.Huang X, Zhou X, Hu Q, Sun B, Deng M, Qi X, et al. Advances in esophageal cancer: A new perspective on pathogenesis associated with long non-coding RNAs. Cancer Lett [Internet] 2018 Jan [citado 8 Ene 2018];413:94-101. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29104147

  15. 15.Antony H, Wiegmans AP, Wei MQ, Chernoff YO, Khanna KK, Munn AL. Potential roles for prions and protein-only inheritance in cancer. Cancer Metastasis Rev [Internet]. 2012 Jun [citado 8 Ene 2018];31(1-2):1-19. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/22138778

  16. 16.Bratkowski M, Yang X, Liu X. Polycomb repressive complex 2 in an autoinhibited state. J Biol Chem [Internet]. 2017 Aug [citado 8 Ene 2018];292(32):13323-13332. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28607149

  17. 17.Taboada Lugo N. Papel del ácido fólico, zinc y cobre en la prevención primaria de los defectos congénitos. Rev Cubana Med Gen Integ [Internet]. 2016 [citado 8 Ene 2018];32(4):[aprox. 9 p.]. Disponible en: http://revmgi.sld.cu/index.php/mgi/article/view/167/110

  18. 18.Montoya Villegas JC, Satizábal Soto JM, García Vallejo F, Sánchez Gómez A. Perspectiva y comprensión bioquímica del síndrome de Down. El Hombre y la Máquina [Internet]. 2008 Ene-Jun [citado 8 Ene 2018];30:118-129. Disponible en: http://www.redalyc.org/articulo.oa?id=47803011

  19. 19.Taboada Lugo N, Mollineda Trujillo A, Herrera Martínez M, Algora Hernández AE, Noche González G, Noa Machado MD. Niveles séricos de zinc y cobre en madres con descendencia afectada por defectos del tubo neural. Rev Cubana Pediatr [Internet]. 2017 Jul-Sep [citado 8 Ene 2018];89(3):299-309. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312017000300004

  20. 20.Moreno Villares JM. Los mil primeros días de vida y la prevención de la enfermedad en el adulto. Nutr Hospitalaria [Internet]. 2016 [citado 8 Ene 2018];33(Supl 4.):8-11. Disponible en: http://www.redalyc.org/html/3092/309246965003/

  21. 21.Rochtus A, Jansen K, Van Greet C, Freeson K. Nutri-epigenomic studies related to neural tube defects: Does folate affect neural tube closure via changes in DNA methylation? Mini Rev Med Chem [Internet]. 2015 [citado 8 Ene 2018];15(13):1095-102. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/26349489

  22. 22.Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L, Gagnon A, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can [Internet]. 2015 Jun [citado 8 Ene 2018];37(6):534-52. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/26334606

  23. 23.Wang L, Lin S, Zhang J, Tian T, Jin L, Ren A. Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics [Internet]. 2017 Feb [citado 8 Ene 2018];12(2):157-165. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28059605

  24. 24.Toriyama M, Toriyama M, Wallingford JB, Finnell RH. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J [Internet]. 2017 Jul [citado 8 Ene 2018];31(8):3622-3635. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28432198

  25. 25.Park HJ, Bailey LB, Shade DC, Hausman DB, Hohos NM, Meagher RB, et al. Distinctions in gene-specific changes in DNA methylation in response to folic acid supplementation between women with normal weight and obesity. Obes Res Clin Pract [Internet]. 2017 Nov-Dec [citado 8 Ene 2018];11(6):665-676. Disponible en: https://www.sciencedirect.com/science/article/pii/S1871403X17300625

  26. 26.Martorell R, Ascencio M, Tacsan L, Alfaro T, Young MF, Addo Y, et al. Effectiveness evaluation of the food fortification program of Costa Rica: impact on anemia prevalence and hemoglobin concentrations in women and children. Am J Clin Nutr [Internet]. 2015 Jan [citado 8 Ene 2018];101(1): 210-217. Disponible en: https://academic.oup.com/ajcn/article/101/1/210/4564282




2020     |     www.medigraphic.com