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ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2019, Number 3

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Acta Med Cent 2019; 13 (3)

Composición fenólica y actividad antioxidante de las hojas de Psidium friedrichsthalianum (O. Berg) Nied

Sánchez CY, Jorge RME, Pozo BY, Díaz LN, Rodríguez RM, Sánchez FP

Language: Spanish
References: 30
Page: 328-343
PDF size: 305.59 Kb.


ABSTRACT

Introduction: medicinal plants are an important source of antioxidants. Objective: to determine the phenolic composition and antioxidant activity of extracts obtained from the leaves of Psidium friedrichsthalianum (O. Berg) Nied. Method: a preclinical experimental study was carried out with the aim of evaluating, from a toxicological and pharmacological point of view, extracts of the leaves of Psidium friedrichsthalianum (O. Berg) Nied. The chemical composition of the methanolic and ethyl acetate extracts was qualitatively analyzed, the content of phenols, flavonoids and tannins was determined. The antioxidant activity was evaluated in vitro by means of the following assays: 2,2-diphenyl-1-picryl-hydrazyl radical sequestration, total antioxidant capacity, chelating activity, ferric reducing/antioxidant power and ferric thiocyanate method. Ex vivo antioxidant activity was evaluated by inducing lipid peroxidation in Wistar rats. Results: phenols, flavonoids and tannins were the main metabolites identified. The methanolic extract showed higher value of phenolic compounds and flavonoids. The extracts showed antioxidant activity in vitro, the methanolic is the one with best results. Ex vivo evaluation of the extract showed decrease in malondialdehyde concentrations and inhibition of lipid peroxidation in all doses studied with dose-dependent behavior. Conclusions: the methanolic extract of Psidium friedrichsthalianum (O. Berg) Nied shows in vitro and ex vivo antioxidant activity; its phenolic compounds are linked to it.


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