Echenagucia-Echenagucia M

Language: Spanish
References: 22
Page: 86-95
PDF size: 298.45 Kb.

ABSTRACT

The search for the ideal anticoagulant is aimed at obtaining safe drugs in their mechanism of action, easy to administer, ideally with oral formulation, used at a fixed dose with a predictable effect and faster onset of action, with the least amount of side effects and without interactions with other medications or natural biochemical mechanisms, which gives rise to the development of direct oral anticoagulants (DOACs). This review is focused on the monitoring of this type of anticoagulants, so, emphasis is placed on how to guide the monitoring, the requirements, the methods used, as well as alternative strategies to achieve it. Finally, each laboratory should be aware of the effect of direct oral anticoagulants on its reagent system, through reviews in the literature or patient samples, and should use commercial calibrators and controls with care.

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