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ISSN 0210-5187 (Electronic)

2019, Number 1

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Med Cutan Iber Lat Am 2019; 47 (1)

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) in dermatological patients, five years after filler injections for cosmetic purposes

González-Rendón MG, Larrazábal A, Suárez Á, Gutiérrez C, Ortiz-Cáceres W, de Waard JH, Pérez-Alfonzo R

Language: Spanish
References: 19
Page: 34-38
PDF size: 261.16 Kb.


ABSTRACT

Introduction: The ideal filling material used for cosmetic purposes must be safe, biocompatible, non-immunogenic, long-lasting and non-migrating to other tissues. However, this material does not exist yet. Objectives: To characterize the clinical and paraclinical conditions of a group of patients who presented between 2010 and 2011 with complications associated with the application of filling material in an aesthetic procedure. The patients were reevaluated five years later, between 2016 and 2017, to determine prevalence of symptoms compatible with the «autoimmune syndrome induced by adjuvants» (ASIA). Material and methods: A descriptive, longitudinal, cross-sectional study was conducted with 82 patients who were evaluated with a medical exam and a survey. Results: 37.3% had reactivation of local symptoms, in general cutaneous reactions and 29% reported «typical» systemic manifestations of ASIA with 18% (15/24) of them with two or more of the following symptoms: myalgias, myositis or muscle weakness (19/24), arthralgia and/or arthritis (10/24), chronic fatigue, unrefreshing sleep or sleep disorders (10/24) and cognitive impairment or memory loss (3/24). Conclusions: In our group of patients, cutaneous signs were a frequent finding five years after injecting biofillers. In addition, systemic manifestations of a nonspecific autoimmune disease was a frequent finding in about 30 % of the patients, alerting us about the possibility of ASIA in patients with cosmetic fillers.


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