medigraphic.com
ISSN 1561-3062 (Electronic)

2018, Number 2

<< Back Next >>

Revista Cubana de Obstetricia y Ginecología 2018; 44 (2)

Prognostic factors to achieve pregnancy with artificial intrauterine inseminations

Frade GJI, Yánez VC, Almaguer AJA, Cambero MY

Language: Spanish
References: 20
Page: 1-15
PDF size: 396.62 Kb.


ABSTRACT

Introduction: Artificial insemination consists of depositing sperm in the female genital duct in order to achieve pregnancies.
Objective: To evaluate prognostic factors of success for pregnancy and calculate the rate accumulated by cycles of intrauterine insemination.
Method: A descriptive, prospective, analytical and longitudinal study was carried out in cycles ran between 2014 and 2016. Infertile women aging 24 and 41 years were included. We determined type and time of infertility, causes, sperm density and mobility post-capacitation, number of follicles, endometrial thickness, and number of cycles in which insemination was performed. Ultrasound follicular follow-up and controlled ovarian stimulation, according to established protocols, were performed. The results were analyzed using the SPSS 15.0 program. The categories were evaluated in frequencies and percentages.
Results: Two hundred ninety (290) couples were studied with 736 total cycles. The pregnancy rate per cycle and in pairs was 8.3 and 21.0% respectively, ages ranges 33.3 ± 5.2 years. The three significant variables were time of infertility, sperm motility and number of the cycle in which insemination was performed.
Conclusions: The greatest success is achieved in the first two treatment cycles, in couples with less than four years of infertility and sperm motility ≥ 77.6%.


REFERENCES

  1. Pérez E. Atención integral de la infertilidad. Endocrinología, cirugía y reproducción asistida. México: McGraw Hill, 2013; pp: 501 - 9.

  2. De Jonge C. Biological basis for human capacitation. Hum Reprod Update. 2015;11:205-14.

  3. Lewis V, Queenan J, Hoeger K, Stevens J, Guzick D. Clomiphene citrate monitoring for intrauterine insemination timing: a randomized trial. Fertil Steril. 2016;85:401-6.

  4. Duran H, Morshedi M, Kruger T, Oehnninger S. Intrauterine insemination: a systematic review on determinants of success. Hum Reprod Update. 2002;8:373-84.

  5. Tomlinson MJ, Amissah JB, Thompson KA, Kasrai JL, Bentick B. Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success. Human Reproduction. 2014;11:1892-6.

  6. Ombelet W, Puttemans P, Bosmans E. Intrauterine insemination: a first-step procedure in the algorithm of male subfertility treatment. Hum Reprod. 2015;10(Suppl.1):90-102.

  7. Zreik TG, Garcia-Velasco JA, Habboosh MS, Olive DL, Arici A. Prospective, randomized, crossover study to evaluate the benefit of human chorionic gonadotropintimed versus urinary luteinizing hormone-timed intrauterine inseminations in clomiphene citrate-stimulated treatment cycles. FertilSteril. 2017;71:1070-4.

  8. Stone BA, Vargyas JM, Ringler GE, Stein AL, Marrs RP. Determinants of the outcome of intrauterine insemination: analysis of outcomes of 9963 consecutive cycles. Am J Obstet Gynecol. 2016;180:1522-34.

  9. Khalil MR, Rasmussen PE, Erb K, Laursen SB. Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles. Acta Obstet Gynecol Scand. 2015;80:74-81.

  10. Montanaro GM, Kruger TF, Coetzee K, Smith K. Stepwise regresion analysis to study male and female factors impacting on pregnancy rate in an intrauterine insemination programme. Andrología. 2016;33:135-41.

  11. OMS. Manual de laboratorio para el examen del semen humano y de la interacción entre el semen y el moco cervical. 8ª ed. Buenos Aires: Editora Panamericana, 2013.

  12. Goverde AJ, McDonnell J, Vermeiden JP, Schats R. Intrauterine insemination or in vitrofertilization in idiopathic subfertility and male subfertility: a randomized trial and cost effectiveness analysis. Lancet. 2015;355:13-8.

  13. Revised American Society for Reproductive Medicine classification of endometriosis 1996; Fertil Steril. 2015;77:817-21.

  14. Dickey RP, Taylor SN, Lu PY, Sartor BM. Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination. Fertil Steril. 2016;78:1088-95.

  15. Nuojua-Huttunen S, Tomas C, Bloigu R, Tuomivaara L, Martikainen H. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod. 2016;14:698-703.

  16. Cano F, Simon C, Remohi J, Pelicer A. Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. Fertil Steril. 2015;64:584-9.

  17. Van Waart J, Kruger TF, Lombard CJ, Ombelet W. Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review. Hum Reprod Update. 2015;7:495-500.

  18. Ombelet W, Vandeput H, Van De Putte G, Cox A. Intrauterine insemination after ovarian stimulation with clomiphene citrate: predictive potential of inseminating motile count andsperm morphology. Hum Reprod. 2015;12:1458-63.

  19. Hughes EG. The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analyses. Hum Reprod. 2016;12:1865-72.

  20. Daya S, Gumby J, Hughes EG. Randomized controlled trial of follicle stimulating hormone versus human menopausal gonadotropin in in-vitro fertilization. Hum Reprod. 2015;10:1392-6.




2020     |     www.medigraphic.com