2018, Number S2
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Rev Cub Med Int Emerg 2018; 17 (S2)
Pathophysiology of severe traumatic brain injury
Corrêa BSRA, Maeda FL, Ghizoni E, Fernandes JA
Language: English
References: 10
Page: 7.11
PDF size: 509.25 Kb.
Text Extraction
Traumatic brain injury (TBI) is a complex entity involving a group of organs disorders who start with a brain injury. It can be caused by many different etiologies, such as traffic accidents, fire gun shots, falls (more commonly seen in pediatric and elderly people), among many other.
Despite several improvements in traffic legislation, such as helmets obligation for motorcycles, seatbelts for all passenger and also advances in neuro critical care, traumatic brain injuries still cause a lot of victims. It accounts for approximately 40 % of all deaths from acute traumatic injury in the United States. Annually, 200,000 victims of TBI require medical attention. By this reason, it is an economic and social problem involving a large amount of money for prevention, assistance and rehabilitation.
TBI can be classified by its severity according to the Glasgow Coma Score. Other forms of classification TBI is according to its causative mechanisms (penetrating versus non penetrating) or extension (focal or diffuse).
REFERENCES
Algattas H, Huang J. Traumatic Brain Injury pathophysiology and treatments: Early, intermediate, and late phases post-injury. Int J Molecular Sciences. 2013;15(1): 309–341.
Dixon KJ. (2017). Pathophysiology of Traumatic Brain Injury. Physical Medicine and Rehabilitation Clinics of NA. 2017; 28(2), 215–225.
Godoy DA, Lubillo S, Rabinstein AA. Pathophysiology and Management of Intracranial Hypertension and Tissular Brain Hypoxia After Severe Traumatic Brain Injury An Integra-tive Approach. Neurosurgery Clinics of NA. 2018; 29(2):195–212.
Kinoshita K. Traumatic brain injury: Pathophysiology for neurocritical care. Journal of In-tensive Care. 2016; 4(1):1–10.
McGinn MJ, Povlishock JT. Pathophysiology of Traumatic Brain Injury. Neurosurgery Clinics of North America. 2016;27(4): 397–407.
Pearn M L, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, et al. Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cellular and Molecular Neurobiology. 2017; 37(4): 571–585.
Prins M, Greco T, Alexander D, Giza CC. The pathophysiology of traumatic brain injury at a glance. Disease Models & Mechanisms. 2013; 6(6):1307–1315.
Sheriff FG, Hinson H E. (2015). Pathophysiology and clinical management of moderate and severe traumatic brain injury in the ICU. Seminars in Neurology. 2015;35(1): 42–49.
Stocchetti N, Maas A. Traumatic Intracranial Hypertension. New Engl J Med. 2014;370:2121-30.
Williams OH, Tallantyre EC, Robertson NP. (2015). Traumatic brain injury: pathophysiolo-gy, clinical outcome and treatment. Journal of Neurology. 2015;262(5); 1394–1396.