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2018, Number 3

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Rev cubana med 2018; 57 (3)

Clinical microbiological characteristics of Acinetobacter baumannii infection in patients with hematological disorders

García GA, Carnot UJ, Hart CM, Hernández CC, Muñío PJ, Cepero LK, Pardo RIK, Pino LSM

Language: Spanish
References: 29
Page: 5-17
PDF size: 525.63 Kb.


ABSTRACT

Introduction: Infectious complications have become the most frequent cause of mortality in patients with hematological conditions subjected to aggressive therapeutic regimens.
Objective: To characterize Acinetobacter baumannii infection in patients with hematological disorders.
Methods: An ambispective and descriptive study was carried out in the hematology department at Hermanos Ameijeiras Clinical Surgical Hospital from January 2010 to December 2016. Twenty-nine patients, who met the established inclusion criteria, formed the sample.
Results: The average age was 48.3 ± 14.8 years, males were majority (65.5 %). The lymphomas cases were more frequent (48.3 %). Regarding the state of the disease, it was observed that the groups of patients with disease in its initial stage and in complete remission prevailed equally (34.5 %). Febrile neutropenia (48.3 %) and respiratory sepsis (31.1 %) were the most detected clinical manifestations. Patients with some degree of neutropenia were the most frequent (55.1 %), mainly those with severe and very severe neutropenia. The resistance to carbapenems among the infected subjects was 58.6 %. The deceased cases represented 24.1 % and resistance to carbapenems was significantly associated (p< 0.05) with this mortality. Out of the invasive procedures used in these patients, central venous catheter placement was predominant (58.6 %).
Conclusions: A. baumannii infection is more frequent in patients with malignant haematological conditions and who received myeloablative treatment as well as in those who presented severe or very severe neutropenia, mainly exhibiting as a febrile neutropenia. It is very important to point out that mortality due to this biological agent was high, mainly if there is resistance to carbapenems.


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