medigraphic.com
ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2018, Number 4

<< Back Next >>

Rev Cubana Hematol Inmunol Hemoter 2018; 34 (4)

Iron overload: frequent complication ofhematopoietic stem cell transplantation

Forrellat BM

Language: Spanish
References: 29
Page: 41-48
PDF size: 94.43 Kb.


ABSTRACT

Iron overload is common in hematopietic stem cell transplantation (HSCT) recipients. In these patients, pre- and early post-transplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload may be related to other complications such as infections, mucositis, and acute graft-versus-host disease. An elevated ferritin level before allogeneic HSCT is an adverse prognostic factor for overall and nonrelapse mortality. There are several diagnostic tools for iron overload but ferritinis still one of the most used.


REFERENCES

  1. Atilla E, Toprak SK, Demirer T. Iron Overload in Hematopoietic Stem Cell Transplantation. Turk J Hematol 2017;34:1-9. DOI: 10.4274/tjh.2016.0450

  2. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versusHost Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 2015;2:389-401.

  3. Sirvent A, AuquierP, Oudin C, Bertrand Y, Bohrer S, Chastagner P, et al. Prevalence and risk factors of iron overload afterhematopoietic stem cell transplantation for childhood acute leukemia: a LEA study. Bone Marrow Transplant. 2017 Jan;52(1):80- 7. DOI:10.1038/bmt.2016.205.

  4. Majhail NS, DeFor TE, Lazarus HM, Burns LJ. Iron-overload after autologoushematopoietic cell transplantation. Leuk Res. 2009;33:578-9.

  5. Majhail NS, DeFor T, Lazarus HM, Burns LJ. High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors. Biol BloodMarrow Transplant 2008;14:790-4.

  6. Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic celltransplantation. Bone Marrow Transplant 2008;41:997-1003.

  7. Boulingand J, Richard C, Valteau-Couanet D, Orear C, Mercier L, Kessari R, et al. Iron overload exacerbates busulfan-melphalan toxicity through a pharmacodynamic interaction in mice. Pharm Res 2016;33:1913-22.

  8. Karoopongse E, Marcondes AM, Yeung C, Holman Z, Kowdley KV, CampbellJS, et al. Disruption of iron regulation after radiation and donor cellinfusion. Biol Blood Marrow Transplant 2016;22:1173-81.

  9. Armand P, Kim HT, Virtanen JM, Parkkola RK, Itala-Remes MA, Majhail NS, et al. Iron overload in allogeneic hematopoietic cell transplantation outcome: a metaanalysis. Biol Blood Marrow Transplant. 2014 Aug;20 (8):1248-51

  10. Barba P, Valcarcel D, Perez-Simon JA, Fernandez-Aviles F, Pinana JL, MartinoR, et al. Impact of hyperferritinemia on the outcome of reduced intensity conditioning allogeneic hematopoietic cell transplantation for lymphoid malignancies. Biol Blood Marrow Transplant 2013;19:597-601.

  11. Mahindra A, Bolwell B, Sobecks R, Rybicki L, Pohlman B, Dean R, et al. Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma. Biol Blood Marrow Transplant 2008;14:1239-44.

  12. Wang Z, Jia M, Zhao H, Cheng Y, Luo Z, Chen Y, et al. Prognostic impact of pretransplantationhyperferritinemia in adults undergoing allogeneic hematopoietic SCT: a meta-analysis. Bone Marrow Transplant.2014;49:1339-40.

  13. Nakamae M, Nakamae H, Koh S, Nishimoto M, Nakashima Y, Nakane T, et al. Prognostic value and clinical implication of serum ferritin levels following allogeneic hematopoietic cell transplantation. Acta Haematol.2015;133:310-6.

  14. Meyer SC, O'Meara A, Buser AS, Tichelli A, Passweg JR, Stern M. Prognostic impact of posttransplantation iron overload after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:440-4.

  15. Armand P, Sainvil MM, Kim HT, Rhodes J, Cutler C, Ho VT, et al. Does iron overload really matter in stem cell transplantation? Am J Hematol. 2012;87:569-72.

  16. Shankar J, Tiwari S, Shishodia SK, Gangwar M, Hoda S, Thakur R, et al. Molecular Insights Into Development and Virulence Determinants of Aspergilli: A Proteomic Perspective. Front Cell Infect Microbiol. 2018 May 29;8:180. DOI: 10.3389/fcimb.2018.00180.

  17. Chitasombat MN, Kontoyiannis DP. Treatment of mucormycosis in transplant patients: role of surgery and of old and new antifungal agents. Curr Opin Infect Dis. 2016 Aug;29(4):340-5. DOI: 10.1097/QCO.0000000000000277.

  18. Sivgin S, Baldane S, Kaynar L, Kurnaz F, Pala C, Sivgin H, et al. Pretransplant iron overload may be associated with increased risk of invasive fungal pneumonia (IFP) in patients that underwent allogeneic hematopoietic stem cell transplantation (alloHSCT). Transfus Apher Sci 2013;48:103-8.

  19. PullarkatV. Iron Toxicity in Hematopoietic Stem CellTransplantation: Strike while the Iron Is Labile. Acta Haematol. 2014;131:220-1.DOI: 10.1159/000355827

  20. Duca l, Cappelline MD, Baronciani D, Pilo F, Targhetta C, Visani G, et al.Nontransferrin- bound iron and oxidative stress during allogeneic hemopoietic stem cell transplantation in patients with or without iron overload. Am J Hematol. 2018 Sep;93(9):E250-E252.DOI: 10.1002/ajh.25201

  21. Mahindra A, Bolwell B, Sobecks R, Rybicki L, Pohlman B, Dean R, et al. Elevated pretransplant ferritin is associated with a lower incidence of chronic graft-versus hostdisease and inferior survival after myeloablative allogeneic hematopoietic stem cell transplantation. Br J Haematol 2009;146:310-316.

  22. Wahlin A, Lorenz F, Fredriksson M, Remberger M, Wahlin BE, Hägglund H. Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts. Med Oncol 2011;28:552-58.

  23. Maximova N, Gregori M, Boz G, Simeone R, Zanon D, et al. MRI-based evaluation of multiorgan iron overload is a predictorof adverse outcomes in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation. Oncotarget. 2017;8 (45):79650-61.

  24. Leitch HA, Fibach E, Rachmilewitz E. Toxicity of iron overload and iron overload reduction in the setting of hematopoietic stem cell transplantation for hematologic malignancies. Crit Rev Oncol Hematol. 2017;113:156-70.

  25. Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev 2009;23:95-104.

  26. Großekatthöfer M, Güclü ED, Lawitschka A, Matthes-Martin S, Mann G,Minkov M, et al. Ferritin concentrations correlate to outcome of hematopoietic stem cell transplantation but do not serve as biomarker of graft-versus-host disease. Ann Hematol 2013;92:1121-8.

  27. Jarisch A, Salzmann-Manrique E, Cario H, Grosse R, Soerensen J, Fischer R, et al. Serum ferritin is not a reliable predictor to determine iron overload in thalassemia major patients post-hematopoietic stem cell transplantation. Eur J Haematol. 2018 Dec;101(6):791-797. DOI: 10.1111/ejh.13169. Epub 2018 Oct 25.

  28. Breuer W, Ronson A, Slotki IN, Abramov A, Hershko C, Cabantchik ZI. The assessment of serum non transferrin-bound iron in chelation therapy and iron supplementation. Blood 2000;95:2975-82.

  29. Goto T, Ikuta K, Inamoto Y, Kamoshita S, Yokohata E, Koyama D, et al. Hyperferritinemia after adult allogeneic hematopoietic cell transplantation: quantification of iron burden by determining non-transferrin-bound iron. Int J Hematol.2013;97:125-34.




2020     |     www.medigraphic.com