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Revista Médica Sinergia

2019, Number 05

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Revista Médica Sinergia 2019; 4 (05)

Chagas’ heart disease

Hines CKD, Zumbado VR, Castro CV

Language: Spanish
References: 19
Page: 101-110
PDF size: 407.67 Kb.


ABSTRACT

Chagas disease is an infectious disorder caused by the protozoan parasite Trypanosoma cruzi. Due to its estimated burden of disease it is considered the most important parasitic disease in the West. T. cruzi is transmitted mainly through a vector, its main vector is Triatoma dimidiata. When T. cruzi infects its host, it destroys the cells it infects, causing an inflammatory response that affects different organs and tissues. Due to the myocardium’s susceptibility and its low regeneration capacity, the heart is one of the main implicated organs. Chronic Chagasic Heart Disease is the most severe complication of the disease, with a great range of manifestations, going anywhere from an asymptomatic infection up to heart failure with dilated myocardiopathy and sudden death. To diagnose this disease, there are different techniques that can be used according to the phase of the disease. In addition, studies are used for evaluation, in order to accurately characterize the heart condition. The treatment goal is to control the heart failure and prevent thromboembolic events. Specifically, for the treatment against infection, nifurtimox and benznidazole have been proven effective against T. cruzi.


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