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2019, Number 2

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Rev Hosp Jua Mex 2019; 86 (2)

Electromagnetic stimulation attenuates the depressive behavior induced by 6-hydroxidopamine in rat

Morales-Sandoval JJ, García-Rivera OU, Juárez-Domínguez DA, Moreno-Fitz J, Medina-Salazar I, Elías-Viñas D, Verdugo-Díaz L

Language: Spanish
References: 30
Page: 70-77
PDF size: 216.18 Kb.


ABSTRACT

Introduction: Recently, extremely low frequency electromagnetic fields (EMF-EBF) have received considerable attention because of their potential therapeutic effect. In particular, EMFs are applied in some types of depressive disorders, but their usefulness in the treatment of other neurodegenerative diseases has also been reported. However, there are few reports of the effect of electromagnetic stimulation on Parkinson’s disease (PD) and its association depressive disorder. Objective: Evaluate the antidepressant effect of EMF-EBF exposure in an animal model of PD through Forced Swim Test (FST). Material and methods: Hemi-Parkinson was induced in Wistar rats with 6-OHDA. EMF-EBF (2.4 mT, 2 hours/day) was applied during different periods to animals (intact, with false lesion and with lesion). The periods of stimulation were 2, 4 or 6 months. At the end of the corresponding periods, the NF test was performed on all the animals in order to measure depressive parameters. The measured parameters were: latency, number and time of immobility. At the end of the FST, the animals were sacrificed and their brains were processed with an immunohistochemistry against thyroxine hydroxylase (TH) to corroborate the correct injury. Results: Both groups intact and with false lesions did not show differences on the parameters measured, either by the application of EMF-EBF or by periods of stimulation. Animals with hemi-Parkinson that received electromagnetic stimulation significantly decreased latency and elevated immobility time. The electromagnetic treatment significantly decreased the immobility time in animals with 6-OHDA. Conclusions: EMF-EBF decreases the depression measured by the forced swimming test at four months of treatment in the animal model of PD. Therefore, the effect of EMF-EBF depends on the time of stimulation in the model of hemi-Parkinson studied.


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