2018, Number 3
<< Back
Enf Infec Microbiol 2018; 38 (3)
Complicated chickenpox with Fournier gangrene associated with nonsteroidal anti-inflammatory drugs (NSAIDS) use in a child
De Lara HJ, Alanís EC, Zermeño GE, Moreno VJ, Santos CL, Reyes HKL, Reyes GU, López CG, Matos ALJ, Gutiérrez OCH
Language: Spanish
References: 16
Page: 93-98
PDF size: 360.84 Kb.
ABSTRACT
We present the case of a male infant with varicella, who received naproxen and paracetamol in the first days, later
he developed a volume increase in the right inguinal region, painful and serohematic secretion in the right perineal
area. Patients was hospitalized and treatment was started with acyclovir, clindamycin plus amikacin. Inguinoescrotal
US was done founding multiple abscesses.
Streptococcus pyogenes and
Staphylococcus aureus were cultured from
the secretion. Extensive debridement was performed and a VAC system was subsequently applied. One month later,
grafts were performed in the perineal area, a month later their management was assessed as external. Importance
of varicella vaccine application is emphasized, to avoid this type of complications. Avoid self-medication with NSAIDS
is necessary. An early diagnosis of perineal lesions is necessary to avoid the high mortality of these complications.
REFERENCES
Bonhooefer, J. et al., “Prospective surveillance of hospitalizations associated with varicella zoster virus infections in children and adolescents”, Euro J Pediat, 2005, 164: 364-370.
Peterson, C.I., Mascola, I. y Chao, S.M., “Children hospitalized for varicella: a pre vaccine review”, Pediatr, 1996, 129: 529-536.
Morpugo, E. y Galandiu, K., “Fournier gangrene”, Surg Clin N Am, 2002, 82: 1213-1224.
Frank, M., “Musculoskeletal infections in children”, Pedatr Clin North Am, 2005, 52: 1083-1086.
Kiran, R.P., “Fournier gangrene: a review of 1 726 cases”, Br J Surg, 2000, 87: 718-728.
Silva, J.A. y Velázquez, M.F., “Fournier gangrene in newborn”, Med Hosp Infant Mex, 1990, 47: 48-50.
Zerr, D.M. y Rubens, C.E., “nsaids and necrotizing fasciitis”, Pediatr Infec Dis J, 1999, 18: 724-725.
Siuyri, O.P. y Grolleau, S., “Severe necrotizing soft tissue infections and nonsteroidal anti-inflammatory drugs”, Clin Exp Dermatol, 2008, 33: 249-255.
Ekingen, G., Isken, T. y Agir, H., “Fournier gangrene in childhood: a report 3 infant patients”, J Pediatr Surg, 2008, 3: 39-42.
Ameh, E.A., Daudá, M. y Sabiu, I., “Fournier gangrene in neonates and infants”, Eur J Pediatr Surg, 2004, 14: 418-421.
Adams, Jr., C., Mata, J.A. et al., “Fournier gangrene in children”, Urology, 1990, 35: 439.
Falcone, P.A., Pricolo, V.E. y Edstrom, L.E., “Necrotizing fasciitis in children as a complication of chickenpox’s”, Pediatr, 1988, 27: 339-343.
Guneren, E., Keskin, M.U. y Yasal, O.A., “Fournier gangrene as a complication of varicella in a 15-month-old boy”, Pediatr Surg, 2002, 37: 1632-1633.
Mikaeloff, Y., Kezouh, A. y Suissa, S., “Nonsteroidal anti- inflammatory drug use and risk of severe skin and soft tissue complications in patients with varicella or zoster disease”, Br J Clin Pharmacol, 2008, 65 (2): 203-209.
Endres Whitaker, R. y Ghorbani, R., “Oral aspirin and ibuprofen increase cytokine synthesis of il-1b and of tumor necrosis factor-a ex vivo”, Immunology, 1996, 87: 264-270.
Kjosen, B., Bassoe, H. y Solberg, C., “Influence of phenylbutazone on leukocyte glucose metabolism and function”, J Reticuloendothelial Soc, 1976, 20 (6): 447-455.