medigraphic.com
Órgano Oficial de la Sociedad Mexicana de Angiología y Cirugía Vascular

2019, Number 1

<< Back Next >>

Rev Mex Angiol 2019; 47 (1)

Revisión en úlceras venosas: Epidemiología, fisiopatología, diagnóstico y tratamiento actual

Sánchez-Nicolat NE, Guardado-Bermúdez F, Arriaga-Caballero JE, Torres-Martínez JA, Flores-Escartín M, Serrano-Lozano JA, González-Villegas P, Sánchez-Burgoa N

Language: Spanish
References: 54
Page: 26-38
PDF size: 312.21 Kb.


ABSTRACT

Venous ulcers are the most serious expression of chronic venous disease conditioned by continuous venous hypertension, a situation that generates significant costs for the health sector and for the patient. The objective of this manuscript is to describe in a comprehensive manner the current available treatments, with the most recent evidence in relation to the different treatment approaches: medical, pharmacological, surgical and wound care to condition a favorable healing and prevention of recurrence of this pathology.


REFERENCES

  1. Abbade LPF, Lastória S. Venous ulcer: epidemiology, physiopathology, diagnosis and treatment. Int J Dermatol 2005; 44(6): 449-56.

  2. Alavi A, Sibbald RG, Phillips TJ, Miller OF, Margolis DJ, Marston W, et al. What’s new: Management of venous leg ulcers: Approach to venous leg ulcers. J Am Acad Dermatol 2016; 74(4): 627–40; quiz 641–2.

  3. Nicolaides AN, Cardiovascular Disease Educational and Research Trust, European Society of Vascular Surgery, The International Angiology Scientific Activity Congress Organization, International Union of Angiology, Union Internationale de Phlebologie at the Abbaye des Vaux de Cernay. Investigation of chronic venous insufficiency: A consensus statement (France, March 5-9, 1997). Circulation 2000; 102(20): E126-163.

  4. Hankin CS, Knispel J, Lopes M, Bronstone A, Maus E. Clinical and cost efficacy of advanced wound care matrices for venous ulcers. J Manag Care Pharm JMCP 2012; 18(5): 375-84.

  5. Browse NL, Burnand KG. The cause of venous ulceration. Lancet Lond Engl 1982; 2(8292): 243-5.

  6. Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JA. Causes of venous ulceration: a new hypothesis. Br Med J Clin Res Ed 1988; 296(6638): 1726-7.

  7. Claudy AL, Mirshahi M, Soria C, Soria J. Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers. J Am Acad Dermatol 1991; 25(4): 623-7.

  8. Falanga V, Eaglstein WH. The “trap” hypothesis of venous ulceration. Lancet Lond Engl 1993; 341(8851): 1006-8.

  9. Peyton BD, Rohrer MJ, Furman MI, Barnard MR, Rodino LJ, Benoit SE, et al. Patients with venous stasis ulceration have increased monocyte-platelet aggregation. J Vasc Surg 1998; 27(6): 1109-15; discussion 1115-6.

  10. Powell CC, Rohrer MJ, Barnard MR, Peyton BD, Furman MI, Michelson AD. Chronic venous insufficiency is associated with increased platelet and monocyte activation and aggregation. J Vasc Surg. 1999 Nov;30(5):844–51.

  11. O’Donnell TF, Passman MA. Clinical practice guidelines of the Society for Vascular Surgery (SVS) and the American Venous Forum (AVF)—Management of venous leg ulcers. Introduction. J Vasc Surg 2014; 60(2 Suppl.): 1S- 2S.

  12. Marston W, Tang J, Kirsner RS, Ennis W. Wound Healing Society 2015 update on guidelines for venous ulcers. Wound Repair Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc 2016; 24(1): 136-44.

  13. Lees TA, Lambert D. Patterns of venous reflux in limbs with skin changes associated with chronic venous insufficiency. Br J Surg 1993; 80(6): 725-8.

  14. Labropoulos N, Leon M, Geroulakos G, Volteas N, Chan P, Nicolaides AN. Venous hemodynamic abnormalities in patients with leg ulceration. Am J Surg 1995; 169(6): 572-4.

  15. Mosti G, Mattaliano V, Partsch H. Inelastic compression increases venous ejection fraction more than elastic bandages in patients with superficial venous reflux. Phlebology 2008; 23(6): 287-94.

  16. Partsch H, Clark M, Mosti G, Steinlechner E, Schuren J, Abel M, et al. Classification of compression bandages: practical aspects. Dermatol Surg Off Publ Am Soc Dermatol Surg Al 2008; 34(5): 600-9.

  17. Partsch B, Partsch H. Calf compression pressure required to achieve venous closure from supine to standing positions. J Vasc Surg 2005; 42(4): 734-8.

  18. Wong IKY, Andriessen A, Charles HE, Thompson D, Lee DTF, So WKW, et al. Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. JEADV 2012; 26(1): 102-10.

  19. Barwell JR, Davies CE, Deacon J, Harvey K, Minor J, Sassano A, et al. Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial. Lancet Lond Engl 2004; 363(9424): 1854-9.

  20. Partsch H, Flour M, Smith PC, International Compression Club. Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP. Int Angiol J Int Union Angiol 2008; 27(3): 193-219.

  21. O’Meara S, Tierney J, Cullum N, Bland JM, Franks PJ, Mole T, et al. Four layer bandage compared with short stretch bandage for venous leg ulcers: systematic review and meta-analysis of randomised controlled trials with data from individual patients. BMJ 2009; 338: b1344.

  22. Alavi A, Sibbald RG, Phillips TJ, Miller OF, Margolis DJ, Marston W, et al. What’s new: Management of venous leg ulcers: Treating venous leg ulcers. J Am Acad Dermatol 2016; 74(4): 643–64; quiz 665–6.

  23. Lurie F, Bittar S, Kasper G. Optimal Compression Therapy and Wound Care for Venous Ulcers. Surg Clin North Am 2018; 98(2): 349–60.

  24. Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb compression bandages? Am J Med 2000; 109(1): 15-9.

  25. Mosti G, et al. Compression therapy in mixed ulcers increases venous output and arterial perfusion. J Vasc Surg 2012; 55(1): 122-8. Available from: https:// www.ncbi.nlm.nih.gov/pubmed/21944912

  26. Nelson EA, Mani R, Vowden K. Intermittent pneumatic compression for treating venous leg ulcers. Cochrane Database Syst Rev 2008; (2): CD001899.

  27. Tate S, Price A, Harding K. Dressings for venous leg ulcers. BMJ 2018; 361: k1604.

  28. O’Meara S, Martyn-St James M, Adderley UJ. Alginate dressings for venous leg ulcers. Cochrane Database Syst Rev 2015; (8): CD010182.

  29. Saco M, Howe N, Nathoo R, Cherpelis B. Comparing the efficacies of alginate, foam, hydrocolloid, hydrofiber, and hydrogel dressings in the management of diabetic foot ulcers and venous leg ulcers: a systematic review and meta-analysis examining how to dress for success. Dermatol Online J 2016; 22(8).

  30. Mosti G. Wound care in venous ulcers. Phlebology 2013; 28(Suppl. 1): 79-85.

  31. Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, et al. A Randomized Trial of Early Endovenous Ablation in Venous Ulceration. N Engl J Med 2018.

  32. Ioannou CV, Giannoukas AD, Kostas T, Kafetzakis A, Liamis A, Touloupakis E, et al. Patterns of venous reflux in limbs with venous ulcers. Implications for treatment. Int Angiol J Int Union Angiol 2003; 22(2): 182-7.

  33. Vowden KR, Vowden P. Preventing venous ulcer recurrence: a review. Int Wound J 2006; 3(1): 11–21.

  34. Gohel MS, Barwell JR, Taylor M, Chant T, Foy C, Earnshaw JJ, et al. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial. BMJ 2007; 335(7610): 83.

  35. Nelson EA, Bell-Syer SEM. Compression for preventing recurrence of venous ulcers. Cochrane Database Syst Rev 2014; (9): CD002303.

  36. Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg 2011; 53(5 Suppl.): 2S-48S.

  37. O’Donnell TF, Passman MA, Marston WA, Ennis WJ, Dalsing M, Kistner RL, et al. Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg 2014; 60(2 Suppl.): 3S-59S.

  38. Gagne PJ. Analysis of Threshold Stenosis by Multiplanar Venogram and Intravascular Ultrasound for Predicting Clinical Improvement After Iliofemoral Vein Stenting: Results From the VIDIO Study. J Vasc Surg Venous Lymphat Disord 2017; 5(1): 157.

  39. Baldwin MJ, Moore HM, Rudarakanchana N, Gohel M, Davies AH. Post-thrombotic syndrome: a clinical review. J Thromb Haemost JTH 2013; 11(5): 795-805.

  40. Martinez-Zapata MJ, Vernooij RWM, Uriona Tuma SM, Stein AT, Moreno RM, Vargas E, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev 2016; 4: CD003229.

  41. Jull AB, Arroll B, Parag V, Waters J. Pentoxifylline for treating venous leg ulcers. Cochrane Database Syst Rev 2012; 12: CD001733.

  42. Jull A, Waters J, Arroll B. Pentoxifylline for treatment of venous leg ulcers: a systematic review. Lancet Lond Engl 2002; 359(9317): 1550–4.

  43. Coleridge-Smith P, Lok C, Ramelet A-A. Venous Leg Ulcer: A Meta-analysis of Adjunctive Therapy with Micronized Purified Flavonoid Fraction. Eur J Vasc Endovasc Surg 2005; 30(2): 198-208.

  44. Scondotto G, Aloisi D, Ferrari P, Martini L. Treatment of venous leg ulcers with sulodexide. Angiology 1999; 50(11): 883–9.

  45. Zou Y-X, Feng X, Jing Z-P. Efficacy and safety of sulodexide in the treatment of venous ulcers of leg. Pharm Care Res 2007; 7: 22–4.

  46. Wu B, Lu J, Yang M, Xu T. Sulodexide for treating venous leg ulcers. Cochrane Database Syst Rev 2016; (6): CD010694.

  47. Serra R, Gallelli L, Conti A, De Caridi G, Massara Mafalda M, Spinelli F, et al. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs. Drug Des Devel Ther 2014; 519.

  48. Flota-Cervera DLF, Nuricumbo-Vázquez DA, Santana- Vega DD, Guevara-Saldívar DMI, Carrizales-Vázquez DMG, Cardoso-Villaseñor DA, et al. Sulodexida para las úlceras venosas de las piernas: experiencia en México. Rev Mex Angiol 2015; 43(4): 131-7.

  49. González Ochoa A. Sulodexide and phlebotonics in the treatment of venous ulcer. Int Angiol J Int Union Angiol 2017; 36(1): 82-7.

  50. Ibbotson SH, Layton AM, Davies JA, Goodfield MJ. The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. Br J Dermatol 1995; 132(3): 422–6.

  51. de Oliveira Carvalho PE, Magolbo NG, De Aquino RF, Weller CD. Oral aspirin for treating venous leg ulcers. Cochrane Database Syst Rev 2016; 2: CD009432.

  52. Wilkinson EAJ. Oral zinc for arterial and venous leg ul cers. Cochrane Database Syst Rev 2012; (8): CD001273.

  53. Stacey MC, Burnand KG, Layer GT, Pattison M. Transcutaneous oxygen tensions in assessing the treatment of healed venous ulcers. Br J Surg 1990; 77(9): 1050–4.

  54. Belcaro G, Marelli C. Treatment of Venous Lipodermatosclerosis and Ulceration in Venous Hypertension by Elastic Compression and Fibrinolytic Enhancement with Defibrotide Treatment of Venous Lipodermatosclerosis and Ulceration in Venous Hypertension by Elastic Compression and Fibrinolytic Enhancement with Defibrotide. Phlebology 1989; 4(2): 91–106.




2020     |     www.medigraphic.com