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2018, Number 2

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Rev cubana med 2018; 57 (2)

Function of amyloidosis in peripheral neuropathy of patients with sickle cell anemia

Fortún PA, Campo DMC

Language: Spanish
References: 19
Page: 1-9
PDF size: 298.52 Kb.


ABSTRACT

Introduction: The inflammatory condition that accompanies sickle cell anemia can be associated to systemic amyloidosis, a complication of this disease which can also affect the peripheral nerves because of its chronic vaso-occlusive process.
Objectives: To assess the function of amyloidosis in the development of peripheral neuropathy in a group of patients with hemoglobinopathy SS.
Methods: In order to determine if amyloidosis takes part in the development of peripheral neuropathy in patients with sickle cells disease, 45 subjects were studied by means of clinical evaluation, biopsy of abdominal fat and a study of nervous conduction, being evaluated if there was any relation between both disorders.
Results: Signs of predominantly sensitive neuropathy were found, and the alterations of the study of conduction were constant, being verified that the existence of amyloidosis increased the frequency and the severity of neuropathy in these patients. Peroneal nerve´s biopsy demonstrated that amyloidosis was present in two cases.
Conclusions: The results indicate that amiyloidosis is related to the development of peripheral neuropathy in patients with sickle cell anemia.


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