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2018, Number 4

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Revista Cubana de Cirugía 2018; 57 (4)

Use of traxenamic acid in hemorrhages

Piamo MAJ, García RMA

Language: Spanish
References: 31
Page: 72-79
PDF size: 372.87 Kb.


ABSTRACT

According to the present scientific evidence, the administration of a simple economic treatment with anti-fibrinolytic properties such as the tranexamic acid can reduce the blood loss after trauma, and decrease the risk associated to blood transfusions. Tranexamic acid is a synthetic derivative of lysine with pure anti-fibrinolytic activity. Its mechanism of action is based on the joining to the plasminogen lysine bond, which blocks the binding of fibrin to the activating complex of plasminogen-plasmin. This review was aimed at describing the results of the use of tranexamic acid based on available evidence. To this end, a literature search was made in PubMed, SciELO and Clinical Keys databases.


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