2019, Number 1
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Rev Invest Clin 2019; 71 (1)
Small Airway Disease in COPD Associated to Biomass Exposure
Ramírez-Venegas A, Torres-Duque CA, Guzmán-Bouilloud NE, González-García M, Sansores RH
Language: English
References: 65
Page: 70-78
PDF size: 271.31 Kb.
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous entity that may result from different causative
agents and risk factors and may follow diverse clinical courses, including COPD secondary to biomass smoke exposure. At present,
this phenotype is becoming more important for two reasons: first, because at least almost half of the world’s population
is exposed to biomass smoke, and second, because the possibility of it being diagnosed is increasing. Biomass smoke exposure
COPD affects primarily women and is related with insults to the airways occurred during early life. Although constituents of
biomass smoke and tobacco smoke are similar, the physiopathological changes they induce differ depending not only on the
chemical composition (related with the type of fuel used) but also on the particle size and the inhalation pattern. Evidence has
shown that biomass smoke exposure affects the airway, predominantly the small airways causing anthracofibrosis and peribronchiolar
fibrosis changes that will clinically translate into chronic bronchitis symptoms, with a high impact on the quality of
life. In this review, we focus especially on the main epidemiological and clinical differences between COPD secondary to biomass
exposure and COPD caused by tobacco exposure.
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