Pólit F, Pólit A, Molano N

Language: Spanish
References: 15
Page: 144-152
PDF size: 364.58 Kb.

ABSTRACT

Introduction: Primary open-angle glaucoma (POAG) shows exponential growth related to age. Prostaglandin analogues are the drugs of first choice. As a side effect they cause elongation, pigmentation and thickening of the eyelashes. The Demodex is the ectoparasite that is in the skin of the humans and is associated to blefaritis. Their rate of infestation increases with age. Aim: Analyze and compare the prevalence of eyelid infestation by Demodex in elderly patients with POAG, who attend the clinic in a random manner, and who are receiving treatment with prostaglandin analogues. Methods: 110 eyes in treatment with prostaglandin analogues for POAG were included. An eyelash was removed to analyze it under the microscope and observe its probable infestation. The results were compared with a group of patients with similar characteristics who did not use this drug. In addition, an in vitro study with one drop of the different prostaglandin analogues on the slide plate of samples infested with Demodex was carried out to evaluate the direct chemical effect. Results: 36.4% of patients with POAG treated with prostaglandin analogues were infested with Demodex. In the in vitro study the morphological changes that the mites suffered were observed. Conclusions: Although the average age was higher in the group of patients studied, a low prevalence of eyelid infestation of Demodex was observed, which contrasts with other series of patients of the same age who did not receive this medication in which the prevalence of infestation was higher.

REFERENCES

1. Foster PJ, Buhrmann R, Quigley HA, John GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002; 86:238-42.

2. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262-7.

3. Johnstone MA. Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. Am J Ophthalmol. 1997;124(4):544-7.

4. Johnstone MA, Albert DM. Prostaglandin-induced hair growth. Surv Ophthalmol. 2002;47 Suppl 1:S185-202.

5. Morris CL, Stinnett S, Woodward J. The role of bimatoprost eyelash gel in chemotherapy-induced madarosis: an analysis of efficacy and safety. Int Trichology. 2011;3(2):84-91.

6. Norn MS. Incidence of Demodex folliculorum on skin of lids and nose. Acta Ophthalmologica. 1982;60:575-83.

7. Gao YY, Di Pascuale MA, Li W, Liu DT, Baradaran-Rafii A, Elizondo A, et al. High prevalence of ocular Demodex in lashes with cylindrical dandruffs. Invest Ophthalmol Vis Sci. 2005;46:3089-94.

8. Galvis-Ramírez V, Tello-Hernández A, Álvarez-Osorio L, Rey-Serrano JJ. Prevalencia de infección por Demodex folliculorum en pacientes que acuden a consulta general de oftalmología. Rev Salud Pública (Bogotá). 2011;13(6):990-7.

9. Pólit F, Pólit A, Soria J. Riesgo en la cirugía de catarata por infestación palpebral de Demodex folliculorum y su prevalencia, revisión de la técnica diagnóstica. Rev Mex Oftalmol. 2016;90(6):261-7.

10. McCulloch CE, Searle S.R, Neuhaus J.M. Generalized, Linear, and Mixed Models. 2.a ed. Wiley, EE.UU.; 2008.

11. Bates D, Maechler M, Bolker B, Walker S.(2015). Fitting Linear Mixed- Effects Models Using lme4. J Statistical Software. 2015;67(1):1-48.

12. R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria; 2016. URL Disponible en: https://www.R-project.org/.

13. Corredor-Osorio R, Nava Castañeda A, Tovilla Canales JL, Tovilla y Pomar JL, Muñoz Salas S. Blefaritis por Demodex folliculorum. Rev Fac Med UNAM. 2000;43(4):125-9.

14. Gao YY,Di Pascuale MA, Li W, Baradaran-Rafii A, Elizondo A, Kuo CL, et al. In vitro and in vivo killing of ocular Demodex by tea tree oil. Br J Ophthalmol. 2005;89(11):1468-73.

15. Baudouin C. Allergic reaction to topical eye drops. Curr Opin Allergy Clin Immunol. 2005;5:459-63.