2018, Number 1
On the behavior of serum selenium as biochemical predictor of surgical cytoreduction of the digestive tube
Roel P, Orozo M, Martinuzzi A, Cornú M, Saibal K, Sepúlveda M, Núñez A, María VJ
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Language: Spanish
References: 0
Page: 44-54
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ABSTRACT
Rationale: Surgical cytoreduction of digestive neoplasias (SCRDN) usually associates with an increased risk of complications. Preoperative serum selenium might determine response to SCRDN. Objective: To assess the associations between complications after SCRDN and preoperative serum selenium. Study design: Prospective, longitudinal, analytical. Study location: Intensive Care Unit (ICU) of the Comahue Medical Center (Neuquén, Argentina). Study serie: Twenty-eight patients (Males: 42.9%; Average age: 54.9 ± 12.5 years) assisted at the ICU (Average APACHE II: 9.7 ± 3.1; Average Charlson comorbirdity index: 3.7 ± 2.4) between January 1rst, 2016 and December 31th, 2016 (Average ICU length of stay: 11.3 ± 14.1 days) after SCRDN completion (Colon and rectum: 71.4%; Pancreas and biliary duct: 17.9%; Other locations: 10.7%). Methods: Dependencies between occurrence of complications post-SCRDN (death included) and preoperative serum selenium and prealbumin were assessed. Results: Post-SCRDN complications rate was 57.1%. All-causes mortality was 9.1%. Preoperative status of biochemical variables was as follows: Prealbumin < 0.2 g.L-1: 72.7%; Selenium < 80 µg.dL-1: 60.6%. There was no dependency of SCRDN outcome upon the preoperative status of the biochemical variables. Conclusions: Outcome of SCRDN is independent from serum selenium.