Aldama PLI, Cuba RAL, Cruz GY, Aroche AR, García HRA, Naranjo DA, Acosta LY

Language: Spanish
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ABSTRACT

Introduction. Anti-platelet treatment constitutes a fundamental pillar in the approach to cardiovascular disease. Inadequate response to these drugs generates potentially severe consequences, such as acute myocardial infarction, stroke, and death. Methods. A descriptive, cross-sectional observational study was performed in patients with ischemic heart disease diagnosis in the Medical Surgical Research Center. The sample was made up of 80 men and 67 women with an average age of 68.2 ± 12.5 years. Each patient was performed with platelet aggregation study with the model Crono Log 560, using the Born'sturbidimetric method. Results. 38.8 % of the patients presented a moderate response of platelet antiaggregation. Diabetes mellitus and obesity were the most associated risk factors for non-therapeutic response with 76% and 72% each. Previous coronary events were present in 70% of non-responders. Conclusions. There is a great variability of response to antiplatelet drugs with a predominance of moderate response. Non-responder patients were mainly diabetic and obese with previous coronary events.