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Academia Mexicana de Neurología, A.C.

2018, Number 5

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Rev Mex Neuroci 2018; 19 (5)

Otic Neurogenesis

Nuñez-Castruita A, López-Serna N

Language: Spanish
References: 50
Page: 54-63
PDF size: 601.77 Kb.


ABSTRACT

Otic neurogenesis develops through a long series of cellular induction and specification events that progressively transform a set of undifferentiated progenitor cells into functional vestibular and auditory neurons. Every specific stage of development is precisely guided by the expression of a set of genes, growth factors, and molecular pathways, which shapes the individual cellular phenotype and assemble the entire auditory pathway. In this review, we have selected the key moments of neural development in the inner ear; from the mechanisms underlying the formation of otic placode, to the development of synaptic connections between the cochleovestibular ganglion neurons and the sensory hair cells. On this journey, we focus on describing the best known molecular mechanisms underlying the development of otic neurons. The study of otic neurogenesis offers the possibility of understanding congenital and acquired pathologies that result in hearing loss, one of the most common neural deficits in humans.


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