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Federación Mexicana de Ginecología y Obstetricia, A.C.

2018, Number 12

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Ginecol Obstet Mex 2018; 86 (12)

Association between telorragia and breast cancer in a high concentration medical unit

Tenorio-Torres JA, Domínguez-Reyes CA, Monges-Jones J, Mayen- Lemus AS, García-Camarena JA, Gómez-Cuevas CF

Language: Spanish
References: 22
Page: 804-809
PDF size: 230.52 Kb.


ABSTRACT

Objective: To determine the association between telorragia and breast cancer in a Mexican population in a highly concentrated Medical Unit.
Materials and Methods: Observational, retrospective, analytical study in patients with telorragia treated at FUCAM from January 2007 to December 2016. Proportion calculation and a "node type" sub-analysis were carried out, between telorragia plus nodule versus telorragia alone, by means of χ2, relative risk, and 95% confidence interval with statistical package SPSS 23.0.
Results: 169 patients were studied, 42 of them presented a definitive diagnosis of breast cancer. The telorragia was associated in 24.8% to cancer, and when it was associated with nodule the probability of malignancy was 63%. When comparing the subgroups with more nodule vs telorrhagia alone, an OR of 4.2 was found for the first group (95% CI 2.5-6.8, p ‹0.001).
Conclusions: This study showed that the probability of malignancy in cases of telorrhagia alone in the Mexican population in a referral hospital is in the high range in relation to the historical world, and is associated with a nodule, the probability is significantly higher.


REFERENCES

  1. Consenso Mexicano sobre diagnóstico y tratamiento del cáncer mamario. Consenso Mexicano sobre diagnóstico y tratamiento del cáncer mamario. Séptima revisión, Colima 2017;1–141.

  2. Falkenberry SS. Nipple discharge. Obstet Gynecol Clin North Am. 2002;29(1):21-9.

  3. Wong Chung JERE, et al. Does nipple discharge color predict (pre-) malignant breast pathology? Breast J. 2016;22(2):202-8. https://doi.org/10.1111/tbj.12544

  4. Patel BK, et al. Management of nipple discharge and the associated imaging findings. Am J Med. 2015;128(4):353- 60. https://doi.org/10.1016/j.amjmed.2014.09.031

  5. Sauter ER, et al. The association of bloody nipple discharge with breast pathology. Surgery. 2004;136(4):780-5. https:// doi.org/10.1016/j.surg.2004.06.017

  6. Richards T, et al. Nipple discharge: A sign of breast cancer? Ann R Coll Surg Engl. 2007;89(2):124-6. https://doi. org/10.1308/003588407X155491

  7. Chang RYK, et al. Nipple Preservation in Breast Cancer Associated with Nipple Discharge. World J Surg. 2017;41(1):176- 83. https://doi.org/10.1007/s00268-016-3679-7

  8. Zervoudis S, et al. Nipple discharge: Evaluation and management. Gineco.ro. 2008;4(4):230-7.

  9. Kurono S, et al. Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two-dimensional nano-liquid chromatography/nanoelectrospray ionization-mass spectrometry. Proteomics Clin Appl. 2016;10(5):605-13. https://doi.org/10.1002/ prca.201500016

  10. Moriarty AT, et al. Cytology of spontaneous nipple discharge-Is it worth it? Performance of nipple discharge preparations in the college of american pathologists interlaboratory comparison program in nongynecologic cytopathology. Arch Pathol Lab Med. 2013;137(8):1039-42. https://doi.org/10.5858/arpa.2012-0231-CP

  11. Louie LD, et al. Identification of breast cancer in patients with pathologic nipple discharge: does ductoscopy predict malignancy? Am J Surg. 2006;192(4):530-3. https://doi. org/10.1016/j.amjsurg.2006.06.004

  12. Yi-Hong Chou, et al. Clinical and imaging evaluation of nipple discharge. J Med Ultrasound. 2005;13(2):47-59. https://doi.org/10.1016/S0929-6441(09)60078-3

  13. Sakorafas GH. Nipple discharge: current diagnostic and therapeutic approaches. Cancer Treatment Reviewes. 2001;27 (5):275-82. https://doi.org/10.1053/ctrv.2001.0234

  14. Lian ZQ, et al. A nomogram based on mammary ductoscopic indicators for evaluating the risk of breast cancer in intraductal neoplasms with nipple discharge. Breast Cancer Res Treat. 2015;150(2):373-80. https://doi.org/10.1007/ s10549-015-3320-8

  15. Morrogh M, et al. Lessons learned from 416 cases of nipple discharge of the breast. Am J Surg. 2010;200(1):73-80. https://doi.org/10.1016/j.amjsurg.2009.06.021

  16. Sauter ER, et al. Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Detect Prev. 2007;31(1):50-8. https:// doi.org/10.1016/j.cdp.2006.12.004

  17. Lee SJ, et al. ACR Appropriateness Criteria ® Evaluation of Nipple Discharge. J Am Coll Radiol [Internet]. 2017;14(5):S138-53. https://doi.org/10.1016/j. jacr.2017.01.030

  18. Yoon JH, et al. Ultrasonographic evaluation of women with pathologic nipple discharge. 2017;36(October):310-20. doi: [10.14366/usg.17013]

  19. Bahl M, et al. Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge. Am J Roentgenol. 2015;205:203-8.

  20. Tabar L , et al. Efficacy of breast cancer screening by age. New results swedish two-county trial. Cancer. 1995;75(10): 2507-17. https://doi. org/10.1002/1097-0142(19950515)75:10<2507::AIDCNCR2820751017> 3.0.CO;2-H

  21. Chen L, et al. Bloody nipple discharge is a predictor of breast cancer risk: a meta-analysis. Breast Cancer Res Treat (2012) 132:9-14. https://doi.org/10.1007/s10549- 011-1787-5

  22. Lesetedi Ch, et al. Indicators of breast cancer in patients undergoing microdochectomy for pathological nipple discharge in a middle-income country. J Surgical Research. 2017;220: 336-40. https://doi.org/10.1016/j. jss.2017.06.046




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