medigraphic.com

2018, Number 6

<< Back Next >>

Cir Cir 2018; 86 (6)

Remote ischemic preconditioning in liver graft viability

Cordero-Pérez P, Hernández-Guedea M, Jiménez-Pérez JC, Muñoz-Espinosa L, Pérez-Rodríguez E, Zapata-Chavira HA

Language: Spanish
References: 30
Page: 539-547
PDF size: 198.86 Kb.


ABSTRACT

Background: Remote ischemic preconditioning (RIP) in liver transplantation has been suggested experimentally as a strategy to reduce ischemia-reperfusion injury. Objective: Evaluate the effect of RIP on liver graft in cadaveric donors and the impact of various inflammatory mediators in this process. Method: Ten liver transplantation recipients, 5 controls and 5 PIR, were made in the cadaver donors by applying a pneumatic tourniquet in the upper third of both thighs for a period of 10 minutes followed by 10 minutes reperfusion. The determination of interleukine (IL)-1, IL-6, tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), intracellular adhesion molecule (ICAM)-1 was performed as well as hematological and biochemical parameters at various stages of liver transplantation. Results: Significant increase of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase in the early stages of post-liver transplantation were observed, after 72 hours subjects who received liver transplantation subjected to RIP they showed a better response, which was also evident in platelet recovery, which persisted until phase 3 months in this group. IL-6 appears to participate in the early stages of the ischemia-reperfusion injury, contrary to TNF-α that increases until day 7 while ICAM-1 was increased in all phases. Conclusions: In this pilot study the PIR decreased the damage by ischemia-reperfusion injury, although the greatest effect was observed after 72 hours.


REFERENCES

  1. Teoh N, De la Pena A, Farrell G. Hepatic ischemic preconditioning in mice is associated with activation of NF‐κB, p38 kinase, and cell cycle entry. Hepatology. 2002;36:94-102.

  2. Ramírez P, Marín JM, Piñero A, Chávez-Cartaya R, Parrilla P. Investigación experimental aplicada a la clínica: isquemia-reperfusión hepática. Cir Esp. 2000;67:281-91.

  3. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol. 2003;284:15-26.

  4. Wang F, Birch SE, He R, Tawadros P, Szaszi K, Kapus A, et al. Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/ reperfusion injury: the role of High Mobility Group-Box 1. Ann Surg. 2010;251:292-9.

  5. Selzner M, Selzner N, Jochum W, Graf R, Clavien PA. Increased ischemic injury in old mouse liver: an ATP‐dependent mechanism. Liver Transpl. 2007;13:382-90.

  6. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology. 2003;125:917-36.

  7. Peralta C, Serafín A, Fernández-Zabalegui L, Wu ZY, Roselló-Catafau J. Liver ischemic preconditioning: a new strategy for the prevention of ischemia- reperfusion injury. Transplant Proc. 2003;35:1800-2.

  8. Azoulay D, Del Gaudio M, Andreani P, Ichai P, Sebag M, Adam R, et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft’s preservation and function: the ying and the yang. Ann Surg. 2005;242:133-9.

  9. Cescon M, Grazi GL, Grassi A, Ravaioli M, Vetrone G, Ercolani G, et al. Effect of ischemic preconditioning in whole liver transplantation from deceased donors. A pilot study. Liver Transpl. 2006;12:628-35.

  10. Costa FL, Yamaki VN, Gonçalves TB, Coelho JV, Percário S, Brito MV. Combined remote ischemic perconditioning and local postconditioning on liver ischemia-reperfusion injury. J Surg Res. 2014;192:98-102.

  11. Eltzschig HK, Eckle T. Ischemia and reperfusion — from mechanism to translation. Nat Med. 2011;17:1391-401.

  12. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic’ preconditioning protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993;87:893-9.

  13. Wu J, Feng X, Huang H, Shou Z, Zhang X, Wang R, et al. Remote ischemic conditioning enhanced the early recovery of renal function in recipients after kidney transplantation: a randomized controlled trial. J Surg Res. 2014;188:303-8.

  14. Nicholson ML, Pattenden CJ, Barlow AD, Hunter JP, Lee G, Hosgood SA. A double blind randomized clinical trial of remote ischemic conditioning in live donor renal transplantation. Medicine. 2015;94:e1316.

  15. Le Page S, Prunier F. Remote ischemic conditioning: current clinical perspectives. J Cardiol. 2015;66:91-6.

  16. Hausenloy DJ, Yellon DM. Remote ischemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res. 2008;79:377-86.

  17. Konstantinov IE, Arab S, Li J, Coles JG, Boscarino C, Mori A, et al. The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium. J Thorac Cardiovasc Surg. 2005;130:1326-32.

  18. Koneru B, Fisher A, He Y, Klein KM, Skurnick J, Wilson DJ, et al. Ischemic preconditioning in deceased donor liver transplantation: a prospective randomized clinical trial of safety and efficacy. Liver Transpl. 2005; 11:196-202.

  19. Jia JJ, Li JH, Jiang L, Lin BY, Wang L, Su R, et al. Liver protection strategies in liver transplantation. Hepatobiliary Pancreat Dis Int. 2015; 14:34-42.

  20. Czigany Z, Turoczi Z, Bulhardt O, Hegedus V, Lotz G, Rakonczay Z, et al. Remote ischemic conditioning: short-term effects on rat liver ischemic-reperfusion injury. Orv Hetil. 2012;153:1579-87.

  21. Skyschally A, van Caster P, Iliodromitis EK, Schulz R, Kremastinos DT, Heusch G. Ischemic postconditioning: experimental models and protocol algorithms. Basic Res Cardiol. 2009;104:469-83.

  22. Jia J, Li J, Jiang L, Zhang J, Chen S, Wang L, et al. Protective effect of remote limb ischemic perconditioning on the liver grafts of rats with a novel model. PLoS One. 2015;10:e0121972.

  23. Kim WH, Lee JH, Ko JS, Min JJ, Gwak MS, Kim GS, et al. Effect of remote ischemic postconditioning on patients undergoing living donor liver transplantation. Liver Transpl. 2014;20:1383-92.

  24. Jin LM, Liu YX, Zhou L, Xie HY, Feng XW, Li H, et al. Ischemic preconditioning attenuates morphological and biochemical changes in hepatic ischemia/reperfusion in rats. Pathobiology. 2010;77:136-46.

  25. Yan S, Jin LM, Liu YX, Zhou L, Xie HY, Zheng SS. Outcomes and mechanisms of ischemic preconditioning in liver transplantation. Hepatobiliary Pancreat Dis Int. 2010;9:346-54.

  26. Li DY, Shi XJ, Li W, Sun XD, Wang GY. Ischemic preconditioning and remote ischemic preconditioning provide combined protective effect against ischemia/reperfusion injury. Life Sci. 2016;1:76-80.

  27. Novaković-Anucin S, Gnip S, Canak V, Jurisić D, Radović P, Erdeljan S, et al. Laboratory monitoring of the haemostatic system changes during orthotopic liver transplantation. Srp Arh Celok Lek. 2013;141:608-14.

  28. Hartmann M, Szalai C, Saner FH. Hemostasis in liver transplantation: pathophysiology monitoring and treatment. World J Gastroenterol. 2016;22:1541-50.

  29. Pereboom IT, Lisman T, Porte RJ. Platelets in liver transplantation: friend or foe? Liver Transpl. 2008;14:923-31.

  30. Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology. 2005;41 553-8.




2020     |     www.medigraphic.com