2018, Number 6
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Cir Cir 2018; 86 (6)
Surgical outcome and risk factors of bile duct injury repair following cholecystectomy
Martínez-Mier G, Luna-Ortiz HJ, Hernández-Herrera N, Zilli-Hernandez S, Lajud-Barquin FA
Language: Spanish
References: 28
Page: 491-498
PDF size: 192.76 Kb.
ABSTRACT
Background: Bile duct injury during cholecystectomy is a serious complication. Multiple factors may alter their outcome.
Method:
We retrospectively evaluated our results following bile duct injury surgery repair and possible poor outcome risk
factors from January 2008 to January 2017.
Results: 58 patients (72.4% female; mean age 41.8 years) were evaluated. 67.8%
underwent open cholecystectomy as initial surgery. 79.3% of bile duct injury were diagnosed postoperatively. Mean referral
time was 9 weeks and early (‹ 1 week) repair was performed in 27.6%. Most common lesion was Amsterdam type D (55.2%)
and Bismuth-Strasberg E4 (34.5%). Morbidity was 39.6%. Biliary leak occurred in 10.3%, bilio-enteric stricture in 6.9% and
recurrent cholangitis in 12.1%, with 3% perioperative mortality. There was an 81% treatment success rate (McDonald classification).
Risk factors for complications were: low hemoglobin, low albumin, low alkaline phosphatase, biliary stents and E-3-E5
lesions (univariate analysis only). Risk factors for treatment failure were: previous repair outside our center, use of biliary stents and repair later than 1 week after lesion (univariate and multivariate analysis).
Conclusions: Good efficacy and safety outcomes
in bile repair surgery can be achieved in specialized centers. There are possible risk factors influencing outcomes that
should be further validated.
REFERENCES
Gouma DJ, Go PM. Bile duct injury during laparoscopic cholecystectomy and conventional cholecystectomy. J Am Coll Surg. 1994;178:229-33.
Massarweh NN, Devlin A, Symons RG, Broeckel JA, Flum DR. Risk tolerance and bile duct injury: surgeon characteristics, risk-taking preference, and common bile duct injuries. J Am Coll Surg. 2009;209:17-24.
Tantia O, Jain M, Khanna S, Sen B. Iatrogenic biliary injury: 13,305 cholecystectomies experienced by a single surgical team over more than 13 years. Surg Endosc. 2008;22:1077-86.
Flum DR, Cheadle A, Prela C, Dellingwer EP, Chan L. Bile duct injury during cholecystectomy and survival in Medicare beneficiaries. JAMA. 2003;290:2168-73.
Ejaz A, Spolverato G, Kim Y, Dodson R, Sicklick JK, Pitt HA, et al. Longterm health-related quality of life after iatrogenic bile duct injury repair. J Am Coll Surg. 2014;5:923-32.
Lillemoe KD, Melton GB, Cameron JL, Pitt HA, Campbell KA, Talamini MA, et al. Postoperative bile duct strictures: management and outcome in the 1990s. Ann Surg. 2000;232:430-41.
Sicklick JK, Camp MS, Lillemoe KD, Melton GB, Yeo CJ, Campbell KA, et al. Surgical management of bile duct injuries sustained during laparoscopic cholecystectomy. Perioperative results in 200 patients. Ann Surg. 2005;241:786-95.
Mercado MA, Franssen B, Domínguez I, Arriola JC, Ramírez F, Elnecavé A, et al. Transition from a low-to a high-volume centre for bile duct repair: changes in technique and improved outcome. HPB. 2011;13:767-73.
Nuzzo G, Giuliante F, Giovannini I, Murazio M, D’Acapito F, Ardito F, et al. Advantages of multidisciplinary management of bile duct injuries during cholecystectomy. Am J Surg. 2008;195:763-9.
Stewart L, Way LW. Laparoscopic bile duct injuries: timing of surgical repair does not influence success rate. A multivariate analysis of factors influencing surgical outcomes. HPB. 2009;11 516-22.
Schmidt SC, Langrehr JM, Hintze RE, Neuhaus P. Long-term results and risk factors influencing outcome of major bile duct injuries following cholecystectomy. Br J Surg. 2005;92:76-82.
Walsh RM, Henderson JM, Vogt DP, Brown N. Long-term outcome of biliary reconstruction for bile duct injuries from laparoscopic cholecystectomies. Surgery. 2007;142:450-7.
Pottakkat B, Vijayahari R, Prakash A, Singh RK, Behari A, Kapoor VK, et al. Factors predicting failure following high bilio-enteric anastomosis for post-cholecystectomy benign biliary strictures. J Gastrointest Surg. 2010;14:1389-94.
Huang Q, Yao HH, Shao F, Wang C, Hu YG, Hu S, et al. Analysis of risk factors for postoperative complication of repair of bile duct injury after laparoscopic cholecystectomy. Dig Dis Sci. 2014;59:3085-91.
Mercado MA, Chan C, Orozco H, Cano G, Chaparro JM, Galindo E, et al. To stent or not to stent bilioenteric anastomosis after iatrogenic injury. A dilemma not answered? Arch Surg. 2002;137:60-3.
Mercado MA, Vilatoba M, Contreras A, Leal P, Cervantes E, Arriola JC, et al. Iatrogenic bile duct injury with loss of confluence. World J Gastrointest Surgery. 2015;7:254-60.
Perera MT, Silva MA, Hegab B, Muralidharan V, Branhall SR, Mayer AD, et al. Specialist early and intermediate repair of post-laparoscopic cholecystectomy bile duct injuries is associated with an improved long-term outcome. Ann Surg. 2011;253:553-60.
Fisher CP, Fahy BN, Aloia TA, Bass BL, Gaber O, Ghobrial RM. Timing of referral impacts surgical outcomes in patients undergoing repair of bile duct injuries. HPB. 2009;11:32-7.
DeReuver PR, Grossmann I, Busch OR, Obertop H, van Gulik TM, Gouma DJ. Referral pattern and timing of repair are risk factors for complications after reconstructive surgery for bile duct injury. Ann Surg. 2007;245:763-70.
Patrono D, Benvenga R, Colli F, Baroffio P, Romagnoli R, Salizzoni M. Surgical management of post-cholecystectomy bile duct injuries: referral patterns and factors influencing early and long-term outcome. Updates Surg. 2015;67:283-91.
Kirks RC, Barnes TE, Lorimer PD, Cochran A, Siddiqui I, Martine JB, et al. Comparing early and delayed repair of common bile duct injury to identify clinical drivers of outcome and morbidity. HPB. 2016; 18:718-25.
Domínguez I, Sanford DE, Liu J, Hawkins WG, Mercado MA. Timing of surgical repair after bile duct injuries impact postoperative complications but not anastomotic patency. Ann Surg. 2016;264:544-53.
Neuhaus P, Schmidt SC, Hintze RE, Adler A, Veltzke W, Raakow R, et al. Classification and treatment of bile duct lesions following laparoscopic cholecystectomy. Chirurg. 2000;71:166-73.
Bismuth H, Majno PE. Biliary strictures: classification based on the principles of surgical treatment. World J Surg. 2001;25:1241-4.
Strasberg S, Hertl M, Soper N. An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg. 1995; 180:101-25.
Clavien P, Sarr MG, Fong Y. Atlas of upper gastrointestinal and hepato- pancreato-biliary surgery. Berlin Heidelberg: Springer-Verlag; 2007.
McDonald ML, Farnell MB, Nagorney DM, Ilstrup DM, Kutch JM. Benign biliary strictures: repair and outcome with a contemporary approach. Surgery. 1995;118 582-90.
Mercado MA, Chan C, Orozco H, Podgaetz E, Porras DE, De la Medina AR, et al. Low serum albumin is not a contraindication for early iatrogenic bile duct injury repair. Ann Hepatol. 2005;4:184-7.