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2018, Number 3

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Rev Educ Bioquimica 2018; 37 (3)

Implicaciones clínicas de la expresión de genes que codifican para proteínas de las uniones estrechas: el caso de TJP1

Ramírez-Bohórquez E, García-Cruz D, Ortega-Pacheco D, Siliceo-Murrieta JI, Ramón-Canul LG, Ramirez-Garcia SA

Language: Spanish
References: 26
Page: 67-74
PDF size: 362.63 Kb.


ABSTRACT

The TJP1 gene encodes for the ZO-1 protein, from the intercellular tight junctions (TJP), which perform different functions according to their expression, such as in the cell-cell contact, provides mechanical and structural support, regulates the transport of nutrients through the cells. Its highest expression is in epithelial and endothelial cells. It has been proposed that the alteration of the structure or disruption of the TJP1 due to mutations or polymorphisms that lead to change in the structure of ZO-1 or its expression, could be a pathogenic factor in different diseases, since it modifies the architecture and tissue function, such as irritable bowel syndrome, infections by hepatitis C virus, HIV, papilloma virus (HPV), and cardiomyopathies. Considering that in humans the TJP1 gene plays a crucial role in the physiology of tissues; we carry out a brief review of the molecular bases and the implications of the effect of the expression of TJP1 and related TJP genes, during the development of different diseases.


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