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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2018, Number 6

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Rev Invest Clin 2018; 70 (6)

Type 2 Diabetes Mellitus is Associated with Carotid Artery Plaques in Patients with Premature Coronary Heart Disease

Juárez-Rojas JG, Posadas-Romero C, Martínez-Alvarado R, Jorge-Galarza E, Reyes-Barrera J, Sánchez-Lozada LG, Torres-Tamayo M, Medina-Urrutia AX

Language: English
References: 36
Page: 301-309
PDF size: 198.37 Kb.


ABSTRACT

Background: In subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events. Objective: The objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients. Methods: Premature CHD was considered before the age of 55 years in men and before 65 in women. T2DM was defined according to the American Diabetes Association criteria. CAP was defined as a focal structure encroaching the arterial lumen by at least 50% of the surrounding IMT value or with a thickness › 1.5 mm. Results: Among 1196 patients (CHD duration 1.5 years [interquartile range: 0.4-5.6]), 37.2% had T2DM, and 97.8% were on antihypertensive, 94.4% on lipid-lowering, and 97.3% on anti-aggregate treatment. hCIMT prevalence was similar in patients with or without T2DM, whereas CAP prevalence was higher among T2DM patients (17.7% vs. 30.9%; p ‹ 0.001). T2DM showed association with CAP, independently of CHD evolution and glycemic control (odds ratio: 1.57; 95% confidence interval: 1.09-2.26). Conclusions: T2DM has an independent association with CAP. Early detection of recurrent cardiovascular events, with CAP identification, could be useful to prevent complications in patients with CHD.


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