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2018, Number 4

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Gac Med Mex 2018; 154 (4)

Síndrome metabólico y aterosclerosis carotídea subclínica en niños y adolescentes mexicanos con acantosis nigricans

González-Villalobos CG, Guevara-Gutiérrez E, Gutiérrez-Fajardo P, Tlacuilo-Parra JA, Sánchez-Castellanos ME, García-Vargas A, Barba-Gómez JF

Language: Spanish
References: 34
Page: 462-467
PDF size: 174.53 Kb.


ABSTRACT

Introduction: Acanthosis nigricans is a marker of insulin resistance that is associated with metabolic and cardiovascular alterations. Objective: To investigate the frequency of metabolic syndrome and subclinical carotid atherosclerosis in children and adolescents with acanthosis nigricans, and to compare the results between genders. Method: Cross-sectional study, where 30 male and 30 female subjects younger than 18 years of age diagnosed with acanthosis nigricans were included. The presence of metabolic syndrome (Cook’s criteria), cardiovascular risk (ultrasensitive C-reactive protein and [us-CRP]), and carotid atherosclerosis (intima-media thickness [IMT]) was investigated. Descriptive and inferential statistics was used for data analysis. Results: The frequency of metabolic syndrome was 43% (males 42 % versus females 58%, p = 0.58). All patients showed us-CRP abnormal levels: 67% were classified with moderate cardiovascular risk and 27% with high risk. The prevalence of carotid atherosclerosis was 98% (males 49% versus females 51%, p = 0.45). Acanthosis nigricans severity did not influence on the results. Conclusions: Intentional search for metabolic syndrome and subclinical carotid atherosclerosis in Mexican children and adolescents with acanthosis nigricans, regardless of gender or disease severity, will enable the implementation of measures to decrease the morbidity and mortality seen in adult age.


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