Corrales AS, Morales DM, Ávalos GR, González LA, Díaz RD, Celestrin TH

Language: Spanish
References: 0
Page: 1045-1058
PDF size: 137.50 Kb.

ABSTRACT

Introduction: the virological follow-up of patients with hepatitis C is made through the quantitative determination of the viral ribonucleic acid using techniques of molecular biology.
Objectives: to assess the virological behavior of patients with hepatitis C treated with Cuban antivirals.
Materials and methods: a prospective, descriptive study was carried out in 45 patients with hepatitis C who attended the Consultation of Hepatology of the University Hospital “Faustino Pérez”, of Matanzas, in the period from January 2014 to December 2017, treated with PEG-eberon and ribavirin for 48 weeks. Their basal characteristics were analyzed and also the different kinds of answer to the treatment according to the virological results.
Results: female sex, patients aged less than 45 years old, non-treated before and with high viral loads. The fast virological answer was reached in 31 % of the patients, and the total early answer in 19.4 %; at the end of the treatment in 77.1 %, and the sustained virological answer in 59.3 % of the patients. Among the answering ones predominated the fast with sustained virological answer, and among the nonanswering predominated the null ones.
Conclusions: quantitative studies of viral ribonucleic acid are essential for the followup of patients with hepatitis C, because through their basal determinations, during and after the treatment, the answer to the treatment can be evaluated.