Ioannidis O, Chatzidelios C, Mantzoros I, Tatsis D, Kitsikosta L, Chatzakis C, Makrantonakis A, Paraskevas G, Kotidis E, Pramateftakis MG, TsalisK

Language: English
References: 21
Page: 446-449
PDF size: 257.17 Kb.

ABSTRACT

Neuroendocrine carcinoma (NEC) of the colon is a rare and very aggressive tumor with poor prognosis. The current case report presents a 53-year-old male with a 6 cm × 10 cm ascending colon carcinoma, causing large intestine obstruction, with simultaneous multiple hepatic metastases and peritoneal carcinomatosis. Surgical resection of the primary tumor was performed, because of the bowel obstruction, to ameliorate the symptoms before the onset of chemotherapy. Histopathology revealed that the tumor was a small-cell undifferentiated NEC. During the post0operative period, the patient presented pulmonary metastases, and on the 36th post-operative day, death occurred due to respiratory failure.

REFERENCES

1. Jones K, Subramaniam RM, Durnick DK, Peller PJ. F-18-FDG-PET/CT imaging of small cell carcinoma of the colon. Clin Nucl Med 2008;33:645‑6. doi: 10.1097/RLU.0b013e31818130c5.

2. Kim HC, Park SI, Park SJ, et al. Small cell carcinoma of the colon: barium study and CT findings. Br J Radiol 2005;78:255-6.

3. Park JS, Kim L, Kim CH, et al. Synchronous large-cell neuroendocrine carcinoma and adenocarcinoma of the colon. Gut Liver 2010;4:122-5. doi: 10.5009/gnl 2010.4.1.122.

4. Shafqat H, Ali S, Salhab M, Olszewski AJ. Survival of patients with neuroendocrine carcinoma of the colon and rectum: a population-based analysis. Dis Colon Rectum 2015;58:294-303. doi: 10.1097/ DCR.0000000000000298.

5. Miyamoto H, Kurita N, Nishioka M, et al. Poorly differentiated neuroendocrine cell carcinoma of the rectum: report of a case and literal review. J Med Invest 2006;53:317-20.

6. Shia J, Tang LH, Weiser MR, et al. Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol 2008;32:719-31. doi: 10.1097/PAS. 0b013e318159371c.

7. Yaziji H, Broghamer WL Jr. Primary small cell undifferentiated carcinoma of the rectum associated with ulcerative colitis. South Med J 1996;89:921‑4.

8. Grabowski P, Schönfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch 2002;441:256-63.

9. Grabowski P, Schönfelder J, Ahnert-Hilger G, et al. Heterogeneous expression of neuroendocrine marker proteins in human undifferentiated carcinoma of the colon and rectum. Ann N Y Acad Sci 2004;1014:270-4.

10. Kato T, Terashima T, Tomida S, et al. Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colon. Pathol Int 2005;55:524-9.

11. Onoda N, Kobayashi H, Satake K, et al. Neuroendocrine carcinoma of the sigmoid colon: report of a case. Surg Today 1999;29:1079-82.

12. Gaffey MJ, Mills SE, Lack EE. Neuroendocrine carcinoma of the colon and rectum. A clinicopathologic, ultrastructural, and immunohistochemical study of 24 cases. Am J Surg Pathol 1990;14:1010-23.

13. Yasui O, Tsukamoto F, Kudo K. Small cell undifferentiated carcinoma of the ascending colon with rapid enlargement after resection: report of a case and review of the literature. Tohoku J Exp Med 2006;209:361‑7.

14. Matsuda A, Sasajima K, Matsutani T, et al. Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: report of a case. Surg Today 2009;39:990-3. doi: 10.1007/s00595-008‑3941‑1.

15. Power DG, Asmis TR, Tang LH, Brown K, Kemeny NE. High-grade neuroendocrine carcinoma of the colon, long-term survival in advanced disease. Med Oncol 2011;28 Suppl 1:S169-74. doi: 10.1007/s12032-010- 9674-1.

16. Ramage JK, Davies AH, Ardill J, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut. 2005;54 Suppl 4:iv1-16.

17. Pascarella MR, McCloskey D, Jenab-Wolcott J, Vala M, Rovito M, McHugh J. Large cell neuroendocrine carcinoma of the colon: A rare and aggressive tumor. J Gastrointest Oncol 2011;2:250-3. doi: 10 3978/j. issn.2078-6891.2011.026.

18. Oberg K. Neuroendocrine tumors of the gastrointestinal tract: recent advances in molecular genetics, diagnosis, and treatment. Curr Opin Oncol 2005;17:386-91.

19. Rifu K, Koinuma K, Horie H, et al. Sigmoid colon carcinoma with focal neuroendocrine differentiation associated with ulcerative colitis: A case report. Int J Surg Case Rep 2016;23:151-6. doi: 10.1016/j.ijscr. 2016.04.035.

20. Reyes CV, Siddiqui MT. Anaplastic carcinoma of the colon: clinicopathologic study of eight cases of a poorly recognized lesion. Ann Diagn Pathol 1997;1:19-25.

21. Mantzoros I, Savvala N, Ioannidis O, et al. Midgut neuroendocrine tumor presenting with acute intestinal ischemia. World J Gastroenterol 2017;23:8090-6. doi: 10.3748/wjg.v23 i45.8090