Rodríguez RR, Jaime IRA, Triana DJ, Vázquez MJ

Language: Spanish
References: 0
Page: 719-728
PDF size: 394.26 Kb.

ABSTRACT

Introduction: in Bioinformatics the goal of researchers involves obtaining computational models for biological processes that are increasingly closer to real behavior, all this inserted into a general discipline known as Systems Biology. In silico analysis in this area of the biological sciences relies on the use of mathematical-computational methods. Within the analysis in biological systems it is of interesting to be able to compare the structure of different organisms. In this comparison, the metabolism of different organisms as well as the topology of their associated metabolic network will be taken into account. This comparison serves to select the species or strains that best suit a particular application.
Objective: to analyze the viability of the mutation of a biological system to assume functions of another.
Method: for this analysis, the BioOpt computer systems were used, which focuses on the analysis of the flow balance, using linear programming as a mathematical support and CompNet solution that compares metabolic networks based on several metrics and the necessary transformations to carry from one metabolic network to another.
Results: a comparison between two biological systems was made, being able to determine the essential reactions within the metabolism of these organisms and from which they should be modified and which ones eliminated to achieve the mutation from one organism to another.
Conclusions: this work shows an in silico analysis that could help in the determination of whether or not genetic manipulation of an organism is viable so that it assumes function that are defined in another.