Esen A, Frydman J, González MC, Ricciardelli M, Gama N

Language: Spanish
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Page: 1-13
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ABSTRACT

Introduction: Invasive mechanical ventilation is a lifesaving therapy for acute respiratory failure. It is associated with significant morbidity and should be discontinued as soon as possible. The spontaneous breathing trial is the most reliable method to identify patients who are ready for extubation.
Objective: To identify the variables that affect extubation failure despite having successfully spontaneous breathing test.
Method: Prospective observational non controlled study was conducted in all patients from birth to 24 months of age admitted to the Pediatric Intensive Care Unit from May 2014 to December 2015 who complied with the extubation protocol. The variables analyzed were age, use of neuromuscular blockers, use of corticosteroids, days of invasive mechanical ventilation, liver dysfunction, use of vasoactive drugs, PAFI > 100 and renal failure. All variables were analyzed using Chi-Square test. Logistic regression was used.
Results: When comparing patients with successful extubation and with extubation failure, it was observed that age, the use of neuromuscular blockers, the use of corticoids, inotropic drugs and the presence of hepatic failure were associated with extubation failure despite having successfully spontaneous breathing test.
Conclusion: The identification of children at high risk of failure in extubation is a challenge. In the investigacion, the variables that affected the failure of extubation could be identified, homewer, researches with a large number of patients are required to validate this result.