Pérez GM, Perurena LMR, Martínez MG

Language: Spanish
References: 0
Page: 252-265
PDF size: 465.59 Kb.

ABSTRACT

Background: in order to understand the origin of the dysfunctions of the autistic spectrum, an etiological and multifactorial approach is needed. New evidence indicates that imbalances in the composition of the intestinal microbiota can influence unfavorably in the evolutionary course of this illness due to very established physiopathological mechanisms. The article is the result of an extensive literature revision for the design of future research.
Objective: to analyze the existing theoretical information about the role of the intestinal microbiota in the evolution of patients with dysfunctions in autistic spectrum.
Methods: a thematic revision through a bibliographic search carried out from 2000 to 2016 was conducted, without any language barrier. Data bases SciELO, Hinari, BVS, Lilacs, Medline and PubMed were consulted. Thirty documents were selected, including national and international scientific publications. The localized terms in DeSC were: autism, microbiota, intestinal microbiota, disbiosis, disbacteriosis, permeable instestine.
Development: the role of the human microbiota has been redefined and it is recognized now as another organ in the human body. When there is a problem with natural balance, such as Candida - they can grow quickly and aggressively, causing damages in the intestinal permeability of the mucous one and allowing the macromolecules step and metabolic residuals to the sanguine torrent, generating biochemical changes that are reflected in worsening of the autism’s behavior.
Conclusions: in the last years numerous articles that have revolutionized the focus of many pathologies have been published, involving the intestinal disbiosis with the severity of the autistic symptoms. Therefore, a promising investigation field was found, where people should work to identify the involved microorganisms, to define their roles in the evolution of these dysfunctions and to study the therapeutic possibilities to alleviate their symptoms.