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2018, Number 3

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Gac Med Mex 2018; 154 (3)

Urinary neutrophil gelatinase-associated lipocalin as graft dysfunction predictor at one year of kidney transplantation

Serna-Higuita LM, Nieto-Ríos JF, Ocampo-Kohn C, Aristizabal-Alzate A, Zuluaga-Valencia GA, Jaimes-Barragán F

Language: Spanish
References: 38
Page: 275-282
PDF size: 295.05 Kb.


ABSTRACT

Introduction: Recent studies suggest that urinary neutrophil gelatinase-associated lipocalin (uNGAL) is superior to creatinine for renal graft dysfunction early detection, but there are only few studies assessing its usefulness as long-term predictor of said function. Objective: To explore if uNGAL values within the first 48 hours after kidney transplantation predict graft function on the long term. Method: Prospective cohort, where uNGAL values were assessed at 2, 12, 24 and 48 hours post-kidney transplantation. Results: Seventy-nine kidney transplant recipients were evaluated. At one year of follow-up, 30.4% of patients had graft dysfunction. No statistically significant differences were found between the uNGAL values and the renal graft function at one year (p = 0.65); the multivariate analysis showed that no uNGAL value was a predictor marker of graft dysfunction at one year of kidney transplantation. Conclusion: The uNGAL values obtained within the first 48 hours post-transplant were not associated with graft dysfunction at one year of kidney transplantation.


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