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ISSN 2448-8909 (Print)

2018, Number 5

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Med Crit 2018; 32 (5)

Carbamazepine poisoning: case report treated with high-flux hemodialysis

Pérez TJG, Martiñón RR, Figueroa RM, Bautista AMI

Language: Spanish
References: 28
Page: 290-294
PDF size: 151.56 Kb.


ABSTRACT

Carbamazepine is a drug that in overdose can cause life-threatening neurological and cardiovascular abnormalities, either by direct effect or by its active metabolite 10,11-epoxide. In carbamazepine poisoned patients with poor response to initial treatment or severe poisoning, may require the use of extracorporeal elimination techniques such as hemodialysis or hemoperfusion.We describe the case of a 71-year-old woman who ingested an overdose of carbamazepine, diazepam and zolpidem in a suicide attempt, who did not respond favorably to the conservative treatment, so it was necessary to conduct two sessions of high-flux hemodialysis. At the end of the sessions the serum concentration of carbamazepine was normalized and patient showed improvement in her clinical condition. With the development of high-flux hemodialysis membranes it has been possible to increase the clearance of xenobiotics that were considered as moderately dialyzable, which could extend the expectations regarding the usefulness of hemodialysis in the treatment of poisoned patients by this and other xenobiotics.


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