Taboada LN, Herrera MM

Language: Spanish
References: 0
Page: 197-207
PDF size: 179.79 Kb.

ABSTRACT

Introduction: genes encodes a potential information, but the way in which the DNA sequence is translated into a specific phenotype does not depend directly on the sequence itself, but on the interaction with environmental factors and here is where the different epigenetic mechanisms play an important role. Notch signalling pathway is related to an enormous diversity of processes of the embryonic development and its dysfunction is involved in the origin of many congenital anomalies.
Objective: a bibliographic review was aimed at providing updated information on epigenetic mechanisms and Notch signalling pathway in the embryonic process and their importance in the implementation of strategies to prevent different human congenital defects.
Methods: medical literature published in Spanish and English language in January, 2018 was compiled from search engines such as PubMed, Medline, Scielo, Lilacs and Cochrane Library and using appropriate keywords.
Conclusions: the fact that epigenetic alterations are potentially reversible, in contrast to genetic changes as mutations, has important implications for the implementation of strategies to prevent different human congenital defects.